itaconate in A Sentence

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Researchers from Dublin just discovered that a molecule called Itaconate can halt the activity of macrophages.

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Scientists already knew that Itaconate helps to regulate many cell processes in macrophages, but the biochemistry involved was not clear.

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The authors conclude that their findings"demonstrate that Itaconate is a crucial anti-inflammatory metabolite that acts via Nrf2 to limit inflammation and modulate type I interferons.".

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O'Neill and colleagues showed, for the first time, that"Itaconate is required for the activation of the anti-inflammatory transcription factor Nrf2[…] in mouse and human macrophages.".

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It is well known," explains co-senior study author Luke O'Neill, a professor of biochemistry from Trinity College Dublin,"that macrophages cause inflammation, but we have just found that they can be coaxed to make a biochemical called Itaconate.".

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