In the absence of three-dimensional structures for variola proteins, it should be possible to substitute those obtained from the highly similar vaccinia virus.
2
One experimental approach has used a virus called vaccinia into which the gene for PSA had been cloned.
3
Progeny vaccinia and human cytomegalovirus particles utilize early endosomal cisternae for their envelopes.
4
Regulation of plaque size and host range by a vaccinia virus gene related to complement system proteins.
5
The project will start by looking at the vaccinia type I topoisomerase enzyme.
6
The viral cDNA sequence was used to construct vaccinia virus recombinants that expressed either the entire E2 coding sequence or fragments of it.
7
Vaccinia infection of cells can confer protection from IFN on other viruses, e.g. Picornaviruses.