Vaccine in A Sentence

    1

    In 1879 a vaccine for cholera was invented.

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    In 1935, a vaccine for yellow fever was created.

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    Researchers also discovered the vaccine was able to restore normal blood sugar levels without using insulin.

    4

    In 1921, a tuberculosis vaccine was developed in France.

    5

    And Jenner had created this vaccine for smallpox without even understanding the basics of germ theory!

    6

    Dialysis came a few years later, then chemotherapy, then the defibrillator, then the polio vaccine; then came cloning, then a kidney transplant.

    7

    The 1990s brought us a hepatitis A vaccine and artificial muscles.

    8

    In the 1920s, we got a vaccine for diphtheria, pertussis, tuberculosis, and tetanus.

    9

    Partly on account of his inability to share in the amusements of his fellows by reason of a deformity due to vaccine poisoning before he was five (the poison permanently arresting the growth and development of his legs), he was an eager student, and in 1814 he graduated at the College of South Carolina with the highest rank in his class and with a reputation throughout the state for scholarship and eloquence.

    10

    The vaccine is injected into the upper arm.

    11

    The risk of side effects also increases with the number of vaccine doses.

    12

    In Mozambique I have visited the factory where in a clinic they are successfully testing the first ever anti malaria preventive vaccine.

    13

    A stable vaccine was developed, our understanding of the disease expanded, and technology moved forward.

    14

    The meningococcal vaccine contains inactivated bacteria and cannot cause the disease.

    15

    The purpose of any vaccine is to prevent disease.

    16

    Less likely is an allergic reaction to the vaccine.

    17

    If the amounts of vaccine used and the times of the injection are suitably chosen, there may thus be produced by a series of steps a rise of the opsonic index to a high level.

    18

    One of the chief objects in registering the opsonic power in such cases is to avoid the introduction of additional vaccine when the opsonic index is low, that is, during the negative phase, as if this were done a further diminution of the opsonic action might result.

    19

    The vaccine is suspended in the aqueous phase of an oil adjuvant emulsion.

    20

    Thanks to Jenner, Nelmes, Blossom, and Phipps (which sounds like a rather odd law firm), today we have the word "vaccine."

    21

    The meningococcal meningitis vaccine is given by injection (shots) to provide immunization against meningococcal disease and meningitis caused by the bacterium Neisseria meningitides.

    22

    Medical conditions and medications that suppress the immune system can interfere with antibody production in response to a rabies vaccine.

    23

    The vaccine is usually made by sterilizing a virulent culture and the proper dose is ascertained by noting 'the extent to which the power of the leucocytes to envelop and digest the microbes is increased.

    24

    The effect of the injection of a small quantity of vaccine is usually to produce an increase in the opsonic index within a few days.

    25

    President Armando Guebuza administered the first doses of the vaccine in the Maputo suburb of Mavalane as the symbolic launch of the campaign.

    26

    The whooping cough vaccine contains thimerosal, a mercury-based preservative used in vaccines.

    27

    Prior to the research, no proven vaccine existed for the deadly botulism toxin.

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    Presentation Tetanus toxoid Concentrated is an inactivated vaccine containing 150 I.U. per dose (1 ml) purified tetanus toxoid.

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    There was no vaccine for endemic typhus in the Great War.

    30

    Previously vaccinated animals should receive a single booster dose of vaccine each year.

    31

    Carefully attach the vial of reconstituted vaccine to the injection equipment and avoid creating aerosols during the priming process.

    32

    With a grant from the National Foundation for Infant Paralysis, he went to work on a polio vaccine.

    33

    A valid certificate showing that the quadrivalent vaccine has been received is now a requirement for pilgrims to enter Saudi Arabia.

    34

    At age 11 or 12, Td vaccine (tetanus and diphtheria) should be given if at least five years have elapsed since the last dose of DTaP.

    35

    All infants should also receive a series of three hepatitis B vaccine injections as part of their routine immunizations.

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    Children who are mildly ill at the time the shot is due can still get meningococcal vaccine.

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    Pregnant women should not receive the vaccine because it may affect the fetus.

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    Children who get the meningitis vaccine may have mild side effects, such as tenderness, redness, or a painful lump on the skin at the injection site; symptoms usually last one to two days.

    39

    A small percentage of the patients who receive the vaccine develop a slight fever.

    40

    The meningitis vaccine, like any other injection, may in rare cases lead to a serious allergic reaction.

    41

    A health-care provider should file a report using the vaccine adverse events reporting system (VAERS) form.

    42

    If the vaccine is given to children receiving immunosuppressive therapy, as in chemotherapy for cancer or HIV/AIDs, the immune response may not take place.

    43

    Rabies is fatal in humans unless it is prevented with a vaccine.

    44

    The French scientist Louis Pasteur developed the first vaccine against rabies.

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    The vaccine consists of killed rabies virus that, when injected, induces the child's immune system to produce antibodies that bind to and destroy the virus.

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    A second type of rabies vaccine, rabies immune globulin (RIG), provides immediate, short-term protection after exposure to the virus.

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    Purified chick embryo cell (PCEC) vaccine became available in the United States in 1997.

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    Rabies vaccine adsorbed (RVA) is manufactured from virus grown in cell cultures of fetal rhesus monkey lung cells and then inactivated.

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    Human rabies immune globulin (RIG, HRIG) is a vaccine made from human serum that contains high levels of antibodies against rabies.

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    The size and number of vaccine doses are the same for children and adults.

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    Although the same rabies vaccine usually is used throughout an immunization series, there is no evidence of adverse reactions or loss of effectiveness when two different vaccines are used in the same series.

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    For preventative rabies immunization in an unexposed child, an inactivated-rabies vaccine is administered in three 1.0-ml. doses, with the second dose seven days after the first, and the third dose 21 or 28 days after the first.

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    Additional treatment with RIG may interfere with antibody production in response to the inactivated-rabies vaccine.

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    Inactivated-rabies vaccine is administered in 1.0-ml. doses, at three, seven, 14, and 28 days after the first vaccination.

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    Children exposed to rabies following vaccination receive a 1.0-ml. dose of vaccine immediately and a second dose three days later.

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    If a child has exhibited a serious hypersensitivity to a previous rabies vaccine, antihistamines may be used concurrently.

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    However side effects may vary with the brand of vaccine and adverse reactions to rabies vaccines used in some other countries are quite common.

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    Although any vaccine is capable of inducing an allergic reaction, serious reactions to rabies vaccine are very rare.

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    Children who will be taking anti-malarial drugs while traveling in areas with endemic rabies should begin the three-dose regimen of ID vaccine one month prior to travel, before they begin taking drugs to prevent malaria.

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    However, a three-dose, pre-exposure regimen of IM vaccine provides an adequate response even in the presence of anti-malarial drugs.

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    Booster immunization-An additional dose of a vaccine to maintain immunity to the disease.

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    Human diploid cell vaccine (HDCV)-A rabies vaccine in which the virus is grown in cultures of human cells, concentrated, and inactivated for IM or ID injection.

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    Purified chicken embryo cell vaccine (PCEC)-A rabies vaccine in which the virus is grown in cultures of chicken embryo cells, inactivated, and purified for IM injection.

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    Rabies virus adsorbed (RVA)-A rabies vaccine in which the virus is grown in cultures of lung cells from rhesus monkeys, inactivated, and adsorbed to aluminum phosphate.

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    Because no vaccine for HIV is available, the only way to prevent infection by the virus is to avoid behaviors that put a person at risk of infection, such as sharing needles and having unprotected sex.

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    The vaccine helps the body produce antibodies (protective substances) that will prevent an individual from contracting polio.

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    Attempts to immunize children in Indian have met with good results, but Nigeria halted their immunization sites due to rumors that Western donors had tampered with the vaccine to spread HIV and cause sterility in Muslim males.

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    No vaccine yet developed had managed to produce a ' neutralizing antibody ' response in the body.

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    When used in chickens where maternal antibody still exists, the way in which this vaccine is administered is critical.

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    From there, we purify the antigens in an additional one to two weeks to create the vaccine.

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    Effects of the albumen or whooping cough vaccine induced arthritis were studied.

    72

    Yet he used instruments of an Englishness so attenuated that, like a strain of vaccine, they would not damage a Scottish host.

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    There is currently no licensed vaccine in the world to prevent botulism.

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    For example, the BCG vaccine used to treat bladder cancer.

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    The vaccine is recommended for use in turkey poults or broiler chicks from day old.

    76

    The human polio vaccine has been used to protect chimpanzees in the wild.

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    Now kidney cell cultures from just 10 monkeys provide enough vaccine for everyone in the country.

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    The vaccine is designed to prevent diphtheria, tetanus, pertussis, hepatitis B and polio.

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    The Committee was informed that the Department was having increasing difficulty in getting supplies of single low dose diphtheria vaccine.

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    They therefore decided to test fourteen patients diagnosed with " vaccine encephalopathy " for this mutation.

    81

    These products include erythropoietin (EPO ), paclitaxel and a pneumococcal vaccine.

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    In order to rigorously evaluate the efficacy of this approach, they have developed a prototype " vaccine " for allergies triggered by cats.

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    The vaccine should not be given to pregnant ewes in the last 8 weeks of pregnancy.

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    There is no cure and no available vaccine, but clinically this disease is extremely rare in pet ferrets.

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    My son, despite having an impressive gash on his back was young enough for his baby tetanus vaccine to still be valid.

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    Another vaccine targets a hormone called gastrin, which is normally made by the pancreas.

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    Topics covered include gastroenterology, microbiology, vaccine development and news of clinical trials.

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    Research studies to test a vaccine to protect humans against H5N1 virus are expected to begin in April 2005.

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    Neonate mice passively immunized by suckling from mice fed transgenic potatoes had less diarrhea than neonates unexposed to the vaccine [14] .

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    Since tumors are poorly immunogenic, the second essential element of a cancer vaccine is to increase the strength of the immune response.

    91

    Your G.P. can also inoculate but may take a while to get to get the vaccine in.

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    James Campbell is principal investigator for the vaccine trials at the University of Maryland School of Medicine.

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    More work remains to be done on vaccine efficacy and stability, which would include large-scale field-testing.

    94

    The team showed that this changes the bacterium's ability to cause disease, making lipoproteins a possible route for creating a vaccine.

    95

    Protocol amendment to the gene therapy trial in follicular lymphoma using a DNA vaccine.

    96

    The finished TA-NIC vaccine consists of the protein conjugate adsorbed onto aluminum hydroxide gel adjuvant in a sodium phosphate buffer containing mannitol.

    97

    A vaccine can also consist of the weakened toxins produced by microorganisms.

    98

    The next step will be to find out whether the vaccine produced in goats ' milk also protects monkeys 5.

    99

    You cannot get mumps, measles or rubella from the vaccine.

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    Three companies have licenses for single antigen measles vaccine and one for single antigen mumps vaccine.

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    Sanofi pasteur has signed a contract with the Australian government for the supply of vaccine in the event of a pandemic influenza outbreak.

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    Get the best out of your doctor Baby vaccine overload?

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    Only 4.4% did not receive any whole-cell pertussis vaccine.

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    Jonas Salk, of the University of Pittsburgh, developed the first successful polio vaccine from inactivated poliomyelitis.

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    Tribal patriotism is a powerful vaccine that immunizes the body politic against self-criticism.

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    It... Read Full Article... HPV vaccine - Providing protection or promoting promiscuity?

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    Researchers have developed a plant-based vaccine against bacterial Shiga toxin, and show that it is highly protective in mice.

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    Additionally, information is provided on squamous cell carcinoma, Bowen's Syndrome and vaccine associated sarcomas.

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    The protein could be used to form the basis of a vaccine against sheep scab.

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    Despite appropriate efforts some patients remain unvaccinated, while true vaccine failures may also contribute to pneumococcal infection post splenectomy.

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    Further analysis revealed that ASA were associated with specific lots of vaccine that contained squalene.

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    Both the vaccine and the solvent vials are closed with bromobutyl rubber stoppers of Ph.Eur.

    113

    There are also associated labor costs for administering the vaccine.

    114

    The same trick was used to improve Hib vaccine ten years ago, and has recently been used for pneumococcal vaccine.

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    The aim is to construct a live attenuated vaccine, which should give good protection against all group B strains.

    116

    The production of vaccines, or vaccine antigens respectively, by common technology is very expensive.

    117

    Monkey viruses contaminating batches of oral polio vaccine were carcinogenic.

    118

    Because the rubella vaccine contains a live virus, pregnancy should be avoided for up to 3 months after vaccination.

    119

    The Iraqis claimed the equipment was used to make smallpox vaccine, Tucker said.

    120

    The poultry worker, along with the others involved in the incident, is also being offered seasonal influenza vaccine.

    121

    Microscience's objective is to develop the first oral anthrax vaccine in the shortest possible time.

    122

    This vaccine contained an adenovirus vector containing GP and NP containing vectors.

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    The vaccine concentrate will drain into the diluent vial.

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    Ideally only dilute one vaccine vial at a time.

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    Glycerin acts as a preservative against decomposition, owing to its antiseptic qualities, which also led to its being employed to preserve untanned leather (especially during transit when exported, the hides being, moreover, kept soft and supple); to make solutions of gelatin, albumen, gum, paste, cements, &c. which will keep without decomposition; to preserve meat and other edibles; to mount anatomical preparations; to preserve vaccine lymph unchanged; and for many similar purposes.

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    On July 6 1885, Pasteur tested his pioneering rabies vaccine on man for the first time.

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    Do not expose reconstituted vaccine to direct sunlight or heat.

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    These serotypes are covered by the existing rotavirus vaccine candidates in clinical development.

    129

    That is why persons who have had measles and rubella vaccination before, are less likely to develop side effects from the MMR vaccine.

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    Additionally, information is provided on squamous cell carcinoma, Bowen 's Syndrome and vaccine associated sarcomas.

    131

    Worldwide stocks of smallpox vaccine will be measured at about 90 million - however, many of these were produced in the 1980s.

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    The vaccine, in the form of standardized doses of sporulated oocysts, is normally administered in water during the first two weeks.

    133

    It is spread by mosquitoes and there is no vaccine.

    134

    Smallpox was eradicated worldwide by 1980, and the US stockpiles of vaccine are decades old.

    135

    The vaccine encodes a strong immune alert signal from Fragment C from tetanus toxin.

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    At present it seems reasonable to recommend that tetravalent meningococcal vaccine be given to all persons with LCCD.

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    In addition, thermostable vaccines do not require reconstitution, which is a major cause of vaccine safety and wastage problems.

    138

    Presentation Tetanus Toxoid Concentrated is an inactivated vaccine containing 150 I.U. per dose (1 ml) purified tetanus toxoid.

    139

    Although a toxoid vaccine is available, it has no place in post-exposure treatment.

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    The current vaccine being distributed by the Department of Veterinary Services is a trivalent vaccine, which protects against only three FMD strains.

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    Mice vaccinated with the vaccine generated a strong antibody response against M2.

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    However, the government did award Edward Jenner £ 10,000 to carry on his work in developing a vaccine against smallpox.

    143

    Influenza vaccine uptake in risk groups under 65 years of age was collected for the first time.

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    The World Health Organization recommends the vaccine strains by predicting those viruses most likely to cause outbreaks in any given year.

    145

    Microscience 's objective is to develop the first oral anthrax vaccine in the shortest possible time.

    146

    At present, live attenuated varicella vaccine is not licensed for use in the UK.

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    Wistar claims that the old vials of vaccine may not be exactly the same as the ones used in the trials.

    148

    Influenza split virion inactivated vaccine belongs to a class of medicines called Influenza Vaccines.

    149

    Influenza split virion inactivated vaccine may affect blood tests for certain viruses.

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    The vaccine targets human papillomavirus (HPV), which is widespread in the population.

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    Prevention Chickenpox is now a vaccine preventable disease with the advent of a live attenuated varicella zoster virus vaccine.

    152

    I hope your vet has considered this angle and contacted the vaccine manufacturer to see if other people have reported the same problem.

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    I keep reading that it is not necessary to give a booster every year except for the rabies vaccine.

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    No, she did not check for a respiratory infection when I took her back, nor did she call the manufacturer of the vaccine, as far as I am aware.

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    There is a FeLV vaccine that can be given to uninfected cats.

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    The problem with it is that not every cat that gets the vaccine will be protected, although most will.

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    The vaccine gives some added protection, but it is still important to protect your cat from possible exposure to FeLV positive animals.

    158

    There is currently one feline infectious peritonitis vaccine that is licensed.

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    There has been a large amount of controversy regarding certain vaccines such as the rabies and feline leukemia virus vaccine.

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    Moreover, the FIP vaccine is also garnering a lot of attention due to the fact that it is a live virus vaccine.

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    Theoretically, the FIP vaccine possesses a live virus that will not replicate, but research is proving otherwise.

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    The rabies vaccine raises several issues mainly because, where outdoor cats are concerned, this vaccine is a necessity.

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    Cats who are allowed outdoors but only in contained areas may not require the vaccine on a frequent basis.

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    However, cats in urban areas or a place that offers exposure to a wide variety of animals may need this vaccine annually.

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    Although owners must follow their local municipality's laws regarding rabies vaccinations, there is a high risk of sarcoma associated with this vaccine.

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    Some vets routinely give the vaccine for kennel cough, while others do not.

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    Although the vaccine greatly reduces the risk of infection, remember that it is still possible for your dog to contract another strain of Bordetella.

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    In fact, Fromm introduced the first canine distemper vaccine in the 1930's.

    169

    Until the antibodies in the puppy's bloodstream drop sufficiently, the vaccine will not work, and the puppy may develop parvo.

    170

    Puppies should receive their first parvo vaccine between five to eight weeks old using a high antigen-density vaccine, according to the Merck Veterinary Manual.

    171

    Every three weeks the puppy will require a parvo vaccine booster until it reaches 16 to 20 weeks of age.

    172

    Despite the best vaccine protocol, the differing maternal antibody levels within each puppy will leave some vulnerable to contracting the dangerous virus.

    173

    Entire litters may still develop parvo even after administering vaccines accordingly because the vaccine can't provide sufficient protection against certain aggressive strains of the parvovirus such as CPV-2c.

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    Your dog will require a parvo booster vaccine when he reaches his first birthday, and subsequent booster vaccines every one to three years thereafter, depending on the veterinarian's advice.

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    Maintaining a clean environment, limiting the puppy's contact with other dogs and maintaining a vaccine schedule can all help prevent a puppy from contracting the parvo virus.

    176

    For example, scientists have the capability to put small pox vaccine into the DNA of tomatoes.

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    Both the Centers for Disease Control (CDC) and the Food and Drug Administration (FDA) are involved in monitoring the H1N1 vaccine to ensure that it is safe.

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    Additional immunizations, such as the influenza vaccine, may be recommended.

    179

    As of 2004, there was no vaccine against fifth disease.

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    A vaccine takes advantage of the fact that infection with polio leads to an immune reaction, which will give the person permanent, lifelong immunity from reinfection with the form of poliovirus for which the person was vaccinated.

    181

    Since the year 2000, the Sabin vaccine (also called the oral polio vaccine or OPV) has been discontinued in the United States, although it is still being used in other countries.

    182

    It contains the live, but weakened, poliovirus and because OPV uses the live virus, it has the potential to cause infection in individuals with weak immune defenses (both in the person who receives the vaccine and in close contacts).

    183

    Approximately nine cases a year of vaccine related polio was associated with OPV in the United States.

    184

    The vaccine used in the United States is actually multiple diphtheria and tetanus toxoids combined with acellular pertussis (DTaP).

    185

    The original vaccine, which as of 2004 was still used in other parts of the world, contains whole cells of Bordatella pertussis, the organism that causes pertussis, better known as whooping cough.

    186

    The whole cell vaccine is more likely to cause adverse effects and does not provide any greater immunity.

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    The vaccine is normally given to children somewhere between the ages of two months and seven years of age (prior to their seventh birthday).

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    Moreover, children who are allergic to any component of the vaccine should not receive the drug.

    189

    These children may be treated with DT (diphtheria-tetanus) vaccine.

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    Also, DTP vaccine should be used with caution in patients who are receiving anticoagulant therapy.

    191

    Because DTP vaccine is injected deep into the muscle, it should be given with care to patients receiving anticoagulant therapy.

    192

    Also, immunosuppressant drugs, including steroids and cancer drugs, may reduce the ability of the body to produce antibodies in response to DTP vaccine.

    193

    Although there have been warnings about severe, even fatal reactions to DTP vaccine, these reactions were seen in about one in 140,000 cases with whole cell DTP.

    194

    Children who had seizures due to the vaccine normally made a full recovery with no neurologic problems afterward.

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    Five well-designed studies failed to show a link between DTP vaccine and any chronic nerve conditions.

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    The most serious risk of DTaP vaccine is a severe allergic reaction.

    197

    The reason for not giving this particular vaccine during pregnancy is the risk of transmitting measles to the unborn child.

    198

    New cases of measles began being reported in some countries-including Great Britain-in 2001 because of parents' fears about vaccine safety.

    199

    The combined vaccine for measles, mumps, and rubella (MMR) was claimed to cause autism or bowel disorders in some children.

    200

    The United Nations expressed concern that unwarranted fear of the vaccine would begin spreading the disease in developing countries and ultimately in developed countries as well.

    201

    Parents in Britain began demanding the measles vaccine as a separate dose, and scientists were exploring that option as an alternative to the combined MMR vaccine.

    202

    Unfortunately, several children died during an outbreak of measles in Dublin because they had not received the vaccine.

    203

    Child mortality due to measles is considered largely preventable, and making the MMR vaccine widely available in developing countries is part of WHO strategy to reduce child mortality by two-thirds by the year 2015.

    204

    Although rubella was once a common childhood illness, its occurrence has been drastically reduced since vaccine against it became available in 1969.

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    In the 20 years following the introduction of the vaccine, reported rubella cases dropped 99.6 percent.

    206

    Rubella vaccine is usually given in conjunction with measles and mumps vaccines in a shot referred to as MMR (mumps, measles, and rubella).

    207

    Children receive one dose of MMR vaccine at 12 to 15 months and another dose at four to six years.

    208

    There is a vaccine that protects against four strains of N. meningitidis, but it is not routinely used in the United States.

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    Prior to the release of a mumps vaccine in the United States in 1967, approximately 92 percent of all children had been exposed to mumps by the age of 15.

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    In 1968, the year after the live mumps vaccine was released, only 76 cases were reported for every 100,000 people.

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    The reason for the decline in mumps was the increased usage of the mumps vaccine.

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    A vaccine exists to protect against mumps.

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    The vaccine preparation (MMR) is usually given as part of a combination injection that helps protect against measles, mumps, and rubella.

    214

    Because mumps is still prevalent throughout the world, susceptible persons over the age of one year who are traveling abroad would benefit from receiving the mumps vaccine.

    215

    The mumps vaccine is extremely effective, and virtually everyone should be vaccinated against this disease.

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    As a result, pregnant women should not receive the mumps vaccine because of the possibility of damage to the fetus.

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    Women who have had the vaccine should postpone pregnancy for three months after being vaccinated.

    218

    Unvaccinated persons who have been exposed to mumps should not get the vaccine, as it may not provide protection.

    219

    Persons with minor fever-producing illnesses, such as an upper respiratory infection, should not get the vaccine until the illness has subsided.

    220

    Because mumps vaccine is produced using eggs, individuals who develop hives, swelling of the mouth or throat, dizziness, or breathing difficulties after eating eggs should not receive the mumps vaccine.

    221

    Persons with immune deficiency diseases and/or those whose immunity has been suppressed with anti-cancer drugs, corticosteroids, or radiation should not receive the vaccine.

    222

    The CDC recommends that all children infected with human immunodeficiency disease (HIV) who are asymptomatic should receive an the MMR vaccine at 15 months of age.

    223

    The mumps vaccine has been controversial in the early 2000s because of concern that its use was linked to an increased rate of childhood autism.

    224

    The negative publicity given to the vaccine in the mass media led some parents to refuse to immunize their children with the MMR vaccine.

    225

    In the fall of 2002, the New England Journal of Medicine published a major Danish study disproving the hypothesis of a connection between the MMR vaccine and autism.

    226

    A second study in Finland showed that the vaccine is also not associated with aseptic meningitis or encephalitis.

    227

    The Hib vaccine is an injection that helps protect children from contracting infections due to Haemophilus influenzae type B (Hib), a bacterium that is capable of causing serious illness and potential death in children under age five.

    228

    In general, the vaccine is considered highly effective, with few side effects.

    229

    The Hib vaccine is given in three or four doses during infancy, depending on the brand used.

    230

    Infants under six weeks of age should not receive the Hib vaccine.

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    If a baby has had a severe reaction to Hib vaccine, another dose should not be administered.

    232

    Like any vaccine or medication, Hib vaccine is capable of causing an allergic reaction.

    233

    The Hib vaccine is routinely given at the same time as other childhood vaccines.

    234

    Parents should be aware of the benefits this vaccine provides, as well as its overall safety and effectiveness.

    235

    Tetracyclines should not be used at the same time the patient is receiving a live vaccine.

    236

    Vaccination introduces a vaccine into the body to produce immunity and prevent specific diseases.

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    When a child receives a vaccine, his or her immune system responds by producing antibodies, substances that weaken or destroy disease-causing organisms.

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    When the child comes in contact with live bacteria or viruses of the same kind that are in the vaccine, the antibodies prevent those organisms from making the child sick.

    239

    Building immunity by using a vaccine is called immunization.

    240

    The antibodies are produced to fight the weakened or dead viruses in the vaccine.

    241

    Vaccinations in children began about 1900 with the smallpox vaccine.

    242

    Some vaccines, such as the rabies vaccine, are given only when a child comes in contact with the virus that causes the disease, such as through a dog bite.

    243

    Such treatments are vaccine or immune globulin for hepatitis A, typhoid, meningitis, Japanese encephalitis, and rabies.

    244

    Vaccines are not always effective, and there is no way to predict whether a vaccine will "take" in any particular child.

    245

    When children receive a vaccine, parents should be told about both.

    246

    Children who have had a severe allergic reaction to baker's yeast should not take the hepatitis B vaccine.

    247

    In general, parents of children who have had an unusual reaction to a vaccine in the past should report the reaction to the doctor before taking the same vaccine again.

    248

    Influenza vaccine may reactivate Guillain-Barre syndrome (GBS) in patients who have had it before.

    249

    This vaccine also may worsen illnesses that involve the lungs, such as bronchitis or pneumonia.

    250

    However, women who are at risk of getting specific disease such as polio may receive the vaccine to prevent medical problems in their babies.

    251

    Women should avoid becoming pregnant for three months after taking rubella vaccine, measles vaccine, mumps vaccine, or the combined measles-mumps-rubella (MMR) as these vaccines may cause problems in the unborn baby.

    252

    Women who are breastfeeding should check with their doctors before taking any vaccine.

    253

    Unusual reaction after receiving a vaccine should be reported to the doctor right away.

    254

    When this happens, the effects of the vaccine or the other medicine may change or the risk of side effects may be greater.

    255

    Parents should let the doctor know of all medicines taken by the child and learn whether the possible interactions could interfere with the therapeutic effects of the vaccine or the other medicines.

    256

    There is no evidence that simultaneous administration of vaccines either reduces vaccine effectiveness or increases the risk of adverse events.

    257

    The Childhood Vaccine Injury Act established a federal program for compensating victims of vaccine-related injuries or death.

    258

    Companies that developed and produced vaccines halted or threatened to halt production and serious vaccine shortages developed.

    259

    In response the U.S. Congress passed the Childhood Vaccine Injury Act of 1986 (PL 99-660).

    260

    The Childhood Vaccine Injury Act was part of an initiative to immunize all children against potentially life-threatening diseases.

    261

    When a new vaccine is added to the Vaccine Injury Table, coverage is retroactive for eight years.

    262

    When the CDC recommends a new vaccine for routine administration to children, it may be automatically added to the table.

    263

    Claims can be filed for other vaccines; however, the claimant must prove that the injury was caused by the vaccine.

    264

    Since this can be very difficult to prove, most VICP claims fall within the Vaccine Injury Table.

    265

    The Vaccine Injury Table contains guidelines for evaluating whether the injury or death was vaccine-related.

    266

    For example, a claim that a child's seizures were triggered by a vaccine must include proof that the child's first seizure occurred within three days of the vaccine administration.

    267

    A physician from within the Division of Vaccine Injury Compensation reviews the petition and makes a recommendation.

    268

    Compensation is paid from the Vaccine Injury Compensation Trust Fund that is funded by a 75-cent excise tax on every purchased dose of a covered vaccine.

    269

    Petitions cannot be filed under VICP if a civil action for damages related to a vaccine injury is pending or if damages have been awarded by a court or in a settlement against the manufacturer or vaccine administrator.

    270

    There is no real difference between the VICP and civil litigation except that the defendant is the U.S. Government rather than the vaccine manufacturer.

    271

    Between 1988 and 2004, 6,506 petitions were filed with the VICP, of which 4,246 were claims for autism resulting from the mercury-containing vaccine preservative thimerosal.

    272

    Vaccine Adverse Event Reporting System (VAERS)-A federal government program for reporting adverse reactions to the administration of a vaccine.

    273

    Vaccine Injury Compensation Program (VICP)-A program through which victims of vaccine-induced injury or death can be awarded financial compensation.

    274

    Vaccine Injury Table-The guidelines by which claims to the VICP are evaluated; includes the vaccines, injuries or other conditions, and the allowable time periods for coverage by the VCIP.

    275

    Prevention involves the use of a vaccine against H. influenzae type b (called the Hib vaccine).

    276

    Use of this vaccine has made epiglottitis a very rare occurrence.

    277

    Parents should be aware of the advantages of the Hib vaccine.

    278

    For children, vaccination against tetanus is normally included in a vaccine called DTaP that protects against diphtheria, tetanus, and whooping cough (acellular pertussis).

    279

    A vaccine for hepatitis B is as of 2004 widely used in the United States for routine childhood immunization.

    280

    Children usually receive the first vaccine between birth and two months of age, the second vaccine at one to four months, and the third vaccine at six to 18 months.

    281

    The vaccine is generally required for all children born on or after January 1, 1992, before they enter school.

    282

    The vaccine is available for older children who may have not been immunized before 1992 and is recommended before age 11 or 12.

    283

    If the blood test is positive, the baby should receive vaccine along with hepatitis B immune globulin (HBIG) at birth.

    284

    The second dose of vaccine should be given at one to two months of age and the third dose at six months of age.

    285

    See also Hepatitis A; Hepatitis B vaccine; Vaccination.

    286

    In addition, pregnant women should be especially careful to keep themselves healthy by following good hygiene practices and receiving a flu vaccine if one is recommended.

    287

    Rabies vaccine is available for animals; it is also given to people after exposure.

    288

    Japanese encephalitis vaccine is recommended for those traveling to Asia and staying in affected rural areas during transmission season.

    289

    It is recommended for patients who cannot or should not receive influenza virus vaccine.

    290

    Due to this adverse effect, the vaccine manufacturer discontinued research and production.

    291

    In 2003, another internasal flu vaccine was licensed in the United States, and this vaccine has so far shown no increased occurrence of Bell's palsy.

    292

    However, the Global Advisory Committee on Vaccine Safety continues to monitor these vaccines, and the use of internasal vaccines should be discussed with the family healthcare provider.

    293

    Any child should stay in a doctors office or near medical care for a period of time after receiving injections of an antibiotic or vaccine.

    294

    Prior to the use of the varicella vaccine, chickenpox was a typical part of growing up for most children in the industrialized world.

    295

    Before the varicella vaccine (Varivax) was released for use in 1995, nearly all of the 4 million children born each year in the United States contracted chickenpox, resulting in hospitalization in five of every 1,000 cases and 100 deaths.

    296

    A vaccine for chickenpox became available in the United States in 1995 under the name Varivax.

    297

    Varivax is a live, attenuated (weakened) virus vaccine.

    298

    A single dose of the vaccine was once thought sufficient for children up to age 12; older children and adults received a second dose four to eight weeks later.

    299

    In 1997, the cost of two adult doses of the vaccine in the United States was about $80.

    300

    The vaccine also is not recommended for pregnant women, and women should delay pregnancy for three months following a complete vaccination.

    301

    The vaccine is useful when given early after exposure to chickenpox and, if given in the midst of the incubation period, it can be preventative.

    302

    While there was initial concern regarding the vaccine's safety and effectiveness when first released, the vaccination is in the early 2000s gaining acceptance as numerous states require it for admittance into daycare or public school.

    303

    A study published in 2001 indicates that the varicella vaccine is highly effective when used in clinical practice.

    304

    Although evidence has not ruled out a booster shot later in life, all research addressing the vaccine's effectiveness throughout its six-year use indicates that chickenpox may be the first human herpes virus to be wiped out.

    305

    Although initial concerns questioned if the vaccination might make shingles more likely, studies are beginning in the early 2000s to show the effectiveness of the vaccine in reducing cases of that disease.

    306

    Varivax-The brand name for varicella virus vaccine live, an immunizing agent used to prevent infection by the Herpes (Varicella) zoster virus.

    307

    The vaccine works by causing the body to produce its own protection (antibodies) against the virus.

    308

    They may also develop infection after receiving live (attenuated) polio vaccine.

    309

    This is one of the reasons that live polio vaccine is no longer used routinely in the United States.

    310

    A specific vaccine against Streptococcus pneumoniae can be protective for people with chronic illnesses.

    311

    The flu vaccine protects a person against getting influenza, caused by the influenza virus.

    312

    Live attenuated influenza vaccine (LAIV) was first approved for use in 2003.

    313

    Inactivated influenza vaccine contains killed viruses and is given by intramuscular injection.

    314

    Vaccine manufacturers then make products to protect against these types of flu.

    315

    Unlike the swine flu vaccine used in 1976, flu vaccines in the last decades of the twentieth century and early 2000s have shown no association with Guillain-Barré syndrome (GBS) in children.

    316

    Both types of influenza vaccine may be administered to family members of immunosuppressed patients, as long as the patients do not require a protected environment, although the killed virus vaccine is preferred for this purpose.

    317

    Family members of patients who do require a protected environment, such as people who have had a stem cell transplant, should only receive the killed virus vaccine (injection).

    318

    Children under the age of 13 years rarely have reactions to the flu vaccine.

    319

    Chickenpox vaccine or varicella zoster vaccine (VZV) is an injection that protects children from contracting chickenpox (varicella), one of the most common childhood diseases.

    320

    The vaccine first became available in the United States in 1995 and is produced by Merck & Company under the trade name Varivax.

    321

    The vaccine was clinically tested for safety and effectiveness.

    322

    Producing sufficient quantities of the vaccine to immunize all children against chickenpox has proven to be a major obstacle.

    323

    The vaccine also prevents chickenpox in children exposed to the virus three to five days prior to vaccination.

    324

    The U.S. Food and Drug Administration (FDA) required Merck to follow several thousand children for 15 years, to determine the long-term effects of the vaccine and whether additional booster shots of VZV would be necessary.

    325

    In the United States more children die of chickenpox than of any other disease that can be prevented by a vaccine.

    326

    It is recommended that babies receive a single-dose injection of Varivax between the ages of 12 and 18 months, usually at the same time that they receive their first measles, mumps, and rubella (MMR) vaccine.

    327

    In rare instances it is possible to contract the weakened vaccine strain of varicella from a recently vaccinated child.

    328

    Moreover, children with weakened immune systems should not receive a live virus vaccine such as VZV.

    329

    The National Vaccine Injury Compensation Program helps pay for medical expenses resulting from vaccine reactions.

    330

    Medical personnel or the local health department should file a Vaccine Adverse Event Report.

    331

    However, antiviral drugs for treating herpes viruses, including acyclovir or valacyclovir, should not be administered within 24 hours of Varivax, because these drugs can reduce the effectiveness of the vaccine.

    332

    Booster shot-An additional dose of a vaccine to maintain immunity to the disease.

    333

    In 2003, clinical trials in humans tested a possible vaccine for recurrent urinary tract infections.

    334

    The vaccine was administered via a vaginal suppository.

    335

    Hepatitis A vaccine has been licensed in the United States for use in persons two years of age and older.

    336

    For this reason, much research has gone into developing a vaccine to protect children from this virus.

    337

    Finally, if the hepatitis B vaccine was not given in the hospital, the first shot may be given at this visit.

    338

    If possible, immunosuppressive medications should be suspended during the vaccination series, and the vaccine injections should be intramuscularly.

    339

    In the early 2000s herpes vaccines are being investigated, and an effective vaccine may be available in before 2010.

    340

    Following a ban on the vaccine that lasted nearly one year, the virus spread across Nigeria to 10 African countries that were previously polio-free.

    341

    The inactivated poliovirus vaccine is injected into a muscle or under the skin and is usually given by a health care professional in a hospital, clinic, or provider's office.

    342

    The use of this vaccine must be officially recorded.

    343

    For children, the vaccine is usually started at two months of age and given again at four months of age.

    344

    Serious reactions to the inactivated poliovirus vaccine are rare in small children.

    345

    It is necessary to receive all doses of the vaccine and there is no generic vaccine available.

    346

    Individuals with an immune deficiency disease need to be counseled before taking the vaccine, and anyone with allergic reactions to prior vaccines and preservatives should be cautious.

    347

    There is no preparation necessary for the vaccine; however, if an individual is ill on the scheduled date, it is essential to make arrangements for a follow-up appointment as no dose can be missed.

    348

    Children receiving the inactivated poliovirus vaccine should be carefully observed for 24-72 hours after receiving the injection.

    349

    For problems that may occur following the vaccine, parents are asked to call the vaccine adverse event reporting system toll-free at (800) 822-7967 to report them.

    350

    The health care professional may administer a dose of a non-aspirin pain/fever reliever at the time of the vaccine and advise giving the medicine every four to six hours for 24 hours after the vaccine.

    351

    This may serve to reduce pain and fever associated with the vaccine.

    352

    While it is important to mention these items to the physician, they are not necessarily contraindications for the vaccine.

    353

    Any of these may affect the way the vaccine works.

    354

    Parents need to be aware of any existing allergies in their families that might cause a reaction from vaccines and their preservatives, and they need to be observant of a child for the first 24-72 hours after receiving the vaccine.

    355

    Traveling to other parts of the world may necessitate a booster vaccine if the polio virus is known to be present in that vicinity.

    356

    A vaccine for Lyme disease known as LYMErix was available from 1998 to 2002, when it was removed from the United States market.

    357

    The Centers for Disease Control and Prevention recommends that people get an influenza vaccine injection each year before flu season starts.

    358

    Adults only need one dose of the yearly vaccine, but children under nine years of age who have not previously been immunized should receive two doses with a month between each dose.

    359

    Each season's flu vaccine contains three virus strains that are the most likely to be encountered in the coming flu season.

    360

    When there is a good match between the anticipated flu strains and the strains used in the vaccine, the vaccine is 70-90 percent effective in people under 65.

    361

    Because immune response diminishes somewhat with age, people over 65 may not receive the same level of protection from the vaccine, but even if they do contract the flu, the vaccine diminishes the severity and helps prevent complications.

    362

    The virus strains used to make the vaccine are inactivated and will not cause the flu.

    363

    In the second half of the twentieth century, flu symptoms were associated with vaccine preparations that were not as highly purified as modern vaccines, not to the virus itself.

    364

    In 1976, there was a slightly increased risk of developing Guillain-Barré syndrome, a very rare disorder, associated with the swine flu vaccine.

    365

    This association occurred only with the 1976 swine flu vaccine preparation and as of 2004 had not recurred.

    366

    It should be noted that certain people should not receive an influenza vaccine.

    367

    Infants six months and younger have immature immune systems and will not benefit from the vaccine.

    368

    Since the vaccines are prepared using hen eggs, people who have severe allergies to eggs or other vaccine components should not receive the influenza vaccine.

    369

    Anyone who wants to forego the discomfort and inconvenience of an influenza attack may receive the vaccine.

    370

    When the measles vaccine is needed a single-antigen measles vaccine is given.

    371

    The first dose of the vaccine is given to children 12 to 15 months old.

    372

    The second dose of the MMR vaccine should be given at four to six years of age.

    373

    Before infants and children of 12 months of age or older leave the United States, they should receive two doses of MMR vaccine separated by at least 28 days, with the first dose given on their birthday.

    374

    Infants under 12 months of age should receive a dose of monovalent (single antigen) measles vaccine before departure.

    375

    If monovalent vaccine is not available, no specific contraindication exists to giving MMR to infants six to eleven months of age.

    376

    Infants who receive the monovalent measles vaccine or MMR before their first birthday are vulnerable to all three diseases and should be revaccinated with two doses of MMR.

    377

    The vaccine may also be less effective if it is not given by the proper route.

    378

    There is varying incidence of vaccine reactions.

    379

    An acellular vaccine contains on parts of the cells which can produce immunity in a person receiving the vaccine.

    380

    As of 2004 there is no published evidence showing a benefit to separating the combination MMR vaccine into three individual shots.

    381

    The CDC continues to recommend two doses of the combined MMR vaccine for all children.

    382

    Because signs of autism may appear around the time children receive the MMR vaccine, some parents worry that the vaccine causes autism.

    383

    Research has not found a relationship between MMR vaccine and autism.

    384

    It is sometimes difficult for parents to adhere to the recommended vaccine schedule, including the spacing between doses.

    385

    If the intervals between doses is longer than usual, there is no need to restart the series of any vaccine.

    386

    The pertussis vaccine, most often given as one immunization together with diphtheria and tetanus, has greatly reduced the incidence of whooping cough.

    387

    Unfortunately, in the 1990s, there has been some concern about serious neurologic side effects from the vaccine itself.

    388

    However, several carefully constructed research studies disproved the idea that the pertussis vaccine is the cause of neurologic damage.

    389

    Furthermore, a subsequent formulation of the pertussis vaccine became available.

    390

    The acellular pertussis vaccine appears to greatly reduce the risk of unpleasant reactions to the vaccine, including high fever and discomfort following vaccination.

    391

    The hepatitis B vaccine (HBV or HepB) is an injection that protects children from contracting hepatitis B, a serious disease caused by the hepatitis B virus.

    392

    The hepatitis B vaccine consists of a small protein from the surface of the hepatitis B virus called the hepatitis B surface antigen (HBsAg).

    393

    In many parts of the world, vaccine intervention before birth is required to prevent hepatitis B infection and its consequences in newborns.

    394

    Infants born to mothers who are HBsAg-positive should be tested for anti-HBs three to nine months following their last dose of vaccine.

    395

    The CDC estimates that in 1998 the vaccine prevented 6,800 infections during birth and 18,700 infections in infants and children up to the age of nine.

    396

    Some also continue to question the safety of the vaccine.

    397

    Children should not receive HBV if they are allergic to baker's yeast or thimerosal, are allergic to any other components in a combination vaccine, or have had a previous allergic reaction to HBV.

    398

    Comvax-Hib-HepB, a combination vaccine that protects against the Haemophilus influenzae type B bacterium and the hepatitis B virus.

    399

    Diphtheria-tetanus-pertussis (DTP) vaccine-The standard vaccine used to immunize children against diphtheria, tetanus, and whooping cough.

    400

    A so-called "acellular pertussis" vaccine (aP) is usually used since its release in the mid-1990s.

    401

    While a vaccine for TB does exist (Bacille Calmette-Guerin or BCG vaccine), it is not widely available in the United States and has had conflicting reports about its efficacy.

    402

    Being inoculated with BCG vaccine does not always prevent infection with the disease.

    403

    The vaccine is only recommended for children in the United States if they live with someone who has active TB that cannot be treated or is drug-resistant.

    404

    For instance, children without tonsils and adenoids produce only half the immunity to oral polio vaccine.

    405

    To do so, the HRIG vaccine is administered once, at the beginning of treatment.

    406

    For active immunization, either the HDCV or RVA vaccine is given in a series of five injections.

    407

    It is, however, important to start immunizations, even if it has been weeks or months following a suspected rabid animal bite, because the vaccine can be effective even in these cases.

    408

    Parents may be concerned that children with acute illnesses have compromised immune systems and are less likely to have a positive response to vaccines or may be more likely to develop adverse reaction to the vaccine than healthy children.

    409

    The reason for deferring immunization is to avoid superimposing a reaction to the vaccine on the underlying illness or attributing symptoms of the underlying illness to the vaccine by mistake.

    410

    The PEP regimen consists of one dose of vaccine given at the initial visit as well as one dose of human immune globulin.

    411

    Additional doses of vaccine are given on days three, seven, 14, and 28.

    412

    If you have the antibodies, it means you've had either the vaccine or the illness.

    413

    There has also been some research into a birth control shot that would work like a vaccine.

    414

    He will most likely suggest using condoms and possibly getting a vaccine to protect against strains of the virus.

    415

    In 1954, Jonas Salk changed the face of the NFIP forever when large field trials of his polio vaccine proved successful.

    416

    In 1955, the vaccine was approved for use and millions would be vaccinated.

    417

    As the vaccine went into wide use, the numbers of polio cases reported each year fell from tens of thousands to just a handful.

    418

    Because the H1N1 virus is a new discovery in human cases, the regular vaccines for seasonal flu are ineffective and a special H1N1 vaccine is necessary.

    419

    The nasal spray is not recommended for children younger than two-years-old, and children younger than six- months-old cannot be vaccinated at all because their immune systems cannot cope with the makeup of the vaccine.

    420

    Once the vaccine becomes more widely available, vaccinations are recommended for everyone.

    421

    A regular seasonal flu vaccine and a pneumonia vaccine are also recommended.

    422

    One prominent theory involves a preservative called thimerosal that was once a standard ingredient in many childhood vaccines and is still present in many vaccine preparations.

    423

    This study assessed computerized medical records in the Vaccine Safety Datalink to conclude that rates of autism spectrum disorders and other neurological problems rose consistently with increased exposure to thimerosal in vaccines.

    424

    Another theory on the possible connection between autism and childhood vaccinations involves the MMR vaccine.

    425

    Regressive autism is the form of this disorder that many suspect as being linked to the MMR vaccine, as its onset often occurs after the vaccine has been given.

    426

    The stated goal of authors of this study was to determine whether autism and GI inflammation could be connected with the administration of the MMR vaccine.

    427

    According to the CDC, any correlation between the administration of the MMR vaccine and regressive autism is coincidental, rather than a cause and effect relationship.

    428

    However, a leaked document was posted online that states the Division of Vaccine Injury Compensation concludes that the multiple shots aggravated Hannah's brain disorder.

    429

    On February 12, the U.S. Court of Federal Claims Office of Special Masters found that the measles, mumps and rubella (MMR) vaccine did not cause autism in Michelle Cedillo, Colton Snyder and William Yates Hazelhurst.

    430

    A week later on February 24, the media reported that the same court ruled that the MMR vaccine caused a brain inflammation in Bailey Banks, who later developed pervasive development disorder not otherwise specified (PDD-NOS) in July 2007.

    431

    To understand the February 12 decision better, it is important to learn about the structure of the Vaccine Court.

    432

    The Vaccine Court is the term to describe a section of the U.S. Court of Federal Claims Office of Special Masters that deals with vaccine-related lawsuits.

    433

    Special Masters are appointed to judge cases in Vaccine Court.

    434

    The National Childhood Vaccine Injury Act of 1986 created the National Vaccine Injury Compensation Program (NVICP).

    435

    The NVICP allows people who were injured as the result of a childhood vaccine to petition the federal government for monetary damages.

    436

    Parents or caregivers are only allowed to take a vaccine-related injury case to a civil court after petitioning the Vaccine Court.

    437

    When the Vaccine Court received over 5,000 claims requesting compensation for autism-related vaccine injuries in 2007, the Special Masters requested three test cases.

    438

    The families sought compensation from the NVICP because they believed that the MMR vaccine caused their children's autism.

    439

    On February 12, 2009, the Vaccine Court found that the MMR vaccine did not cause autism in the three children.

    440

    However, it should be noted that this decision only addressed the possible link between autism and the MMR vaccine in combination with thimerosal-containing vaccines, not all childhood vaccinations.

    441

    In fact, the Vaccine Court is in the process of deciding whether thimerosal, a mercury-based preservative, has a connection to autism.

    442

    The Special Masters found the three test cases did not provide sufficient evidence of a connection between the MMR vaccine and autism.

    443

    While the court decision provides strong support for the recent MMR studies and the theory that the MMR vaccine is safe, it is not a conclusive answer to the possible connection between the vaccine and autism.

    444

    In July 2007, the Vaccine Court awarded the family of Bailey Banks compensation for vaccine-related injuries that led to the development of PDD-NOS, a type of autism.

    445

    Bailey Banks contracted a brain inflammation, acute disseminated encephalomyelitis (ADEM) after receiving the MMR vaccine as a toddler.

    446

    The Special Master found that the MMR vaccine caused the complication of ADEM, which ultimately led to the development of PDD-NOS.

    447

    The Bailey Banks ruling provides a possible link between the MMR vaccine and autism through the development of ADEM.

    448

    Many autism experts and families who disagree with the February 2009 ruling point to this case as evidence that the MMR vaccine may cause autism in certain individuals.

    449

    In March 2008, the Vaccine Court awarded Hannah Poling compensation because her childhood vaccinations aggravated a preexisting mitochondrial disorder and caused autism-like symptoms.

    450

    Some doctors disagree with the ruling and believe that the MMR vaccine has harmed certain autistic patients such as Banks and Poling.

    451

    The February 2009 and July 2007 autism vaccination rulings may provoke more questions than answers about the possible connection between autism and the MMR vaccine.

    452

    The question about a connection between the MMR vaccine and autism continues to be a major controversy within the autism community.

    453

    How did the MMR vaccine debate begin and does the vaccine have a possible connection to autism?

    454

    Since 1971, the MMR vaccine has been a part of the standard childhood vaccinations in the USA.

    455

    After the introduction of the MMR vaccine, the incidence of measles declined by 99 percent in the USA.

    456

    The combination of the three viruses in the vaccine could negatively affect a child's immune system.

    457

    An unidentified substance in the vaccine may have a toxic effect on some children.

    458

    The impact of the viruses in the vaccine, the lowered immune system and chronic infection in the gastrointestinal tract could eventually lead to brain damage and cause autism.

    459

    Despite the many questions about the study that originally suggested the MMR vaccine as a possible cause of autism, families all over the world reacted by vaccinating their children less.

    460

    A number of families with autistic children believed the study and claimed that their previously healthy children became ill immediately after receiving the vaccine and eventually developed autism.

    461

    Skeptics argued that the development of autism after receiving the vaccine was coincidental because the disease typically manifests during toddler years.

    462

    The Centers for Disease Control and Prevention (CDC) and medical research groups conducted a number of studies looking for possible connections between the vaccine and autism.

    463

    A number of key studies examined the MMR vaccine.

    464

    The CDC and the Danish Medical Council studied more than 500,000 children over a seven year period and found no evidence that the MMR vaccine affects the development of autism.

    465

    The National Institute of Child Health and Human Development (NICHD) and the CDC studied 351 children with autism and 31 children without autism who all received the MMR vaccine.

    466

    The study did not find evidence of any connection between autism and the vaccine.

    467

    A 2008 study that was published in the Public Library of Science investigated the results of an earlier study that linked the MMR vaccine with autism.

    468

    The study discredited the earlier study and could not find a link between the vaccine and autism.

    469

    ThinkTwice Global Vaccine Institute features a list of documents linking autism with vaccines.

    470

    After significant studies supporting the safety of the MMR vaccine, the CDC, American Academy of Pediatrics and the Institute of Medicine have concluded that there is no link between the MMR vaccine and autism.

    471

    The U.S. Court of Federal Claims Office of the Special Masters found that the MMR vaccine did not cause autism in three test cases that affected more than 5,000 families.

    472

    The current research will reassure many parents about the MMR vaccine's safety.

    473

    However, the significant number of families and experts who believe in a connection between the vaccine and specific cases of autism are still demanding answers.

    474

    This statement was issued soon after the US Court of Federal Claims Office of Special Masters ruled that the MMR vaccine did not cause autism in three test cases that represented more than 5,000 families.

    475

    In fact, the National Vaccine Advisory Committee has approved a CDC proposal to study possible connections between autism and vaccinations.

    476

    There is a significant segment of the autism community that argues that vaccinations are still a possible cause of autism despite the 2009 vaccine court ruling and the discredited 1998 Lancet study, and demand more research into the matter.

    477

    It also lists a 1976 smallpox vaccine study that may be linked to autism.

    478

    Current research, a discredited research study and a high profile federal court case have made the idea of a possible connection between the MMR vaccine and autism less likely.

    479

    Yet, many families of autistic children remain convinced that the MMR vaccine plays some role in the development of autism.

    480

    Yet, when Dr. Andrew Wakefield published a 1998 study in the British medical journal The Lancet that suggested a link between MMR vaccines and autism, parents around the world began to question the safety of the MMR vaccine.

    481

    The controversial study soon became the most cited study in arguments for a vaccine and autism connection.

    482

    Detractors of the study pointed out that the study involved only 12 children, all of whom had preexisting gastrointestinal problems before receiving the MMR vaccine.

    483

    The discredit of the 1998 Wakefield Lancet study has now become a popular example in the argument against a connection between autism and vaccines, especially the MMR vaccine.

    484

    On February 12, 2009, the U.S. Court of Federal Claims Office of the Special Masters (aka Vaccine Court) found that the MMR vaccine did not cause autism in three test cases that represented more than 5,000 families.

    485

    The Vaccine Court found that the three test cases did not provide adequate evidence of a connection between the MMR vaccine and autism.

    486

    The autism vaccination ruling led to many official statements by the mainstream medical community, such as the American Medical Association (AMA), against a connection between the MMR vaccine and autism.

    487

    It is also cited frequently in general arguments for vaccine safety.

    488

    The CDC site also published a page about the safety of the MMR vaccine with a list of studies that support the safety of the vaccine.

    489

    The traditional medical view of a connection between the MMR vaccine, or any childhood vaccine, and autism agrees with the statements made by U.S. Department of Health and Humans Services, the CDC and the AMA.

    490

    The mainstream medical community argues that childhood vaccines, especially the MMR vaccine, is safe and protects children from potentially fatal diseases.

    491

    The general consensus of the traditional medical community is that MMR vaccine is safe and has no connection to autism.

    492

    Despite the mainstream medical opinion, the discredited study and the Vaccine Court ruling, a number of families believe that the MMR vaccine triggered their children's autism.

    493

    These families argue that many autistic children became ill after receiving the MMR vaccine and soon developed autism symptoms.

    494

    Some of these families continue to petition the Vaccine Court for compensation.

    495

    Unfortunately, there is no definitive answer to the question, "Does MMR vaccine cause autism?"

    496

    There is not enough scientific evidence to prove the MMR vaccine causes autism.

    497

    Current studies suggest that there is no link between the MMR vaccine and autism.

    498

    In fact, the National Vaccine Advisory Committee approved the CDC's 2009 proposal to further study any possible connection between vaccinations and autism.

    499

    More research is necessary to determine a more conclusive answer to whether the MMR vaccine has any connection to autism.

    500

    Dr. Andrew Wakefield's high profile autism vaccine study retracted by The Lancet in 2010 remains a controversial issue in the autism vaccine debate.