To get to Termini in Rome, you can take metro lines A and B
or a bus line such as H, if you are staying in the Trastevere neighborhood.
The fastest way to go from Rome to Florence It is by train from the Rome Termini Station, the main one of the city and in case you are not staying near Termini you can easily reach with the metro lines A and B or with several bus lines such as the H,
if you are staying in the Trastevere neighborhood.