Eventually, the advent of mass-production techniques and
semi-synthetic penicillins resolved the supply issues, so this use of Probenecid declined.
Once the acute attack subsides, levels of uric acid can be lowered via lifestyle changes and in those with frequent attacks,
allopurinol or Probenecid provides long-term prevention.
Cimetidine, omeprazole, oxcarbazepine, ticlopidine, topiramate, ketoconazole, itraconazole, disulfiram, fluvoxamine, isoniazid,
erythromycin, Probenecid, propranolol, imipramine,
ciprofloxacin, fluoxetine, and valproic acid prolong the action of diazepam by inhibiting its elimination.