Organoids can be used to study the safety and efficacy of new drugs and
also test the response of tissues to existing medicines.
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Most Organoids contain only a subset of all the cells seen in a real organ,
but lack blood vessels to make them fully functional.
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Lei and
colleagues were able to see that the newborn cells formed skin-like Organoids in a six-step process that started with the dissociated progenitor cells(step one),
which soon aggregated(step two).
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In the case of brain Organoids, scientists have been able to develop neurons
and even make specific brain regions such as the cerebral cortex that closely resemble the human brain.
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Some neuroscientists have warned repeatedly that fellow scientists are“perilously close” to crossing the
ethical red line of growing mini-brains or Organoids in the laboratory that can perceive or feel things.
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In a study in Europe using intestinal Organoids from six patients with an intestine disorder, it
became possible to identify the mutation in a gene that prevented the formation of a healthy intestine.