His chief works were First Lines of the Practice of Physic (1774); Institutions of Medicine (1770); and Synopsis Nosologicae Medicae (1785), which contained his classification of diseases into four great classes - (t) Pyrexiae, or febrile diseases, as typhus fever; (2) Neuroses, or nervous diseases, as epilepsy; (3) Cachexiae, or diseases resulting from bad habit of body, as scurvy; L and (4) Locales, or local diseases, as cancer.