microglial in A Sentence

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    Although important to brain cell health, Microglial cells also produce nitric oxide in reaction to their function as protectors,” Gu said.

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    Peter Bloomfield and his colleagues wanted to know if the activity of Microglial cells is altered in the early stages of schizophrenia.

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    By creating a cell model of neurological stress and monitoring Microglial cell function, Gu's team was able to study FruArg's contribution to brain health.

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    The results suggest that blocking or reducing Microglial activation, with drugs that are already being used to treat other conditions, might alleviate the symptoms of schizophrenia.

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    And post-mortem examinations of brain tissue show that activated Microglial cells are present in higher numbers in people with schizophrenia compared to others, particularly in the frontal and temporal lobes.

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    My hunch is that this is what's going on, and that Microglial activation is part of the disease pathology, as opposed to a protective response,” says senior author Oliver Howes.

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    We didn't continue the study to see whether phagocytosis was further impaired after longer exposures to alcohol, but it appears that these changes in Microglial cells could be a contributing factor to the development of Alzheimer's disease.".

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