Imatinib mesylate is a tyrosine kinase inhibitor IC50 value of
100 nM, 100 nM, 600 nM for v-Abl, c-kit, PDGFR, respectively.
Imatinib Mesylate is a specific tyrosine kinase(abl,
c-kit, and PDGFR) inhibitor and is reported to sensitize cells to radio- or chemo-therapy.
These are prevalent,
and potentially clinically relevant because of the availability of tyrosine kinase inhibitors, such as Imatinib and sunitinib that can block the activity of c-KIT pharmacologically.