huntingtin in A Sentence

1

Generally, people have fewer than 36 repeated glutamines in the polyQ region which results in production of the cytoplasmic protein Huntingtin.

0

2

For the first three or four decades of life, this Huntingtin protein simply floats in the watery cytosol inside brain cells.

0

3

Mutant Huntingtin is expressed throughout the body and associated with abnormalities in peripheral tissues that are directly caused by such expression outside the brain.

0

4

As other influences cause aging in the brain, however, the Huntingtin protein begins to interfere with the various"organelles" or activity centers within the brain cell.

0

5

In the case of the mutant gene that causes Huntington's disease, the'zinc fingers' prevent its expression, thus decreasing the production of the abnormal Huntingtin protein.

0

6

In Huntington's disease there is an alteration in the gene that encodes a protein called Huntingtin, which is essential for the development and maintenance of neurons.

0

7

Researchers have also known for a long time that keeping the neurons in the brain"busy" helps preserve them from the Huntingtin protein, but the production of chemicals outside the neurons in the watery fluids of the brain hurts them.

0