Adjust dosage according to clinical and Hemodynamic parameters including heart rate,
central venous pressure, systemic BP, and urine output.
IIA- moderately pronounced Hemodynamic disturbances in one of the parts of the heart,
working capacity is sharply reduced, even normal exercise leads to severe shortness of breath.
Massive PE causing Hemodynamic instability(shock and/or low blood pressure,
defined as a systolic blood pressure <90 mmHg or a pressure drop of 40 mmHg for >15 min if not caused by new-onset arrhythmia, hypovolemia or sepsis) is an indication for thrombolysis, the enzymatic destruction of the clot with medication.