desmoglein in A Sentence

    1

    Second, during the next phase, these detached desmosomes expose Desmoglein antigens.

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    2

    When I began Rituxan® in January 2013, my Desmoglein levels had jumped from 75 to 128.

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    3

    Since these mice possessed no Desmoglein 3, some other antigen(s) must have been the target of the disease-causing pemphigus antibodies.

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    4

    However, I now believe that antibodies to Desmoglein 3 may be only incidental and that antibodies directed to other antigens may be more directly responsible for causing the disease.

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    5

    Since Desmoglein 3 knockout mice were bred have no Desmoglein 3, and since we documented that there was no anti-Desmoglein 1 antibody in the serum, we conclude that the blister-causing antibody is not directed toward a Desmoglein protein.

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    6

    Although Desmoglein 3(Dsg3) has been well established as a primary target of immunoglobulin(Ig) autoantibodies in PV, there remain several questions regarding the overall distribution of anti-Dsg3 Ig subtypes among patient subsets and considerable controversy regarding whether an isotype switch can be observed.

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    7

    In some areas of the body, there are two Desmogleins present, and both have to be damaged to cause cell detachment- in some areas only one Desmoglein may be present at some level in the skin or mucous membrane, and there only one Desmoglein has to be damaged to cause cell detachment.

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