Because of coelution, the signal for the desired compound was often buried in the noise.
By understanding the mechanisms driving coelution, we can develop more effective separation strategies.
Careful optimization of the mobile phase is crucial to prevent coelution of the target analyte with interfering substances.
Coelution can be a major challenge in the development of diagnostic assays.
Coelution can be a major hurdle in complex mixture analysis using HPLC-MS.
Coelution can be a major obstacle in the development of new analytical methods.
Coelution can be a major obstacle in the development of new therapeutic agents.
Coelution can be a significant limitation in the analysis of complex natural product extracts.
Coelution can be a significant source of error in quantitative proteomics.
Coelution can be a significant source of error in the analysis of environmental samples.
Coelution can be mitigated by adjusting the temperature of the chromatographic column.
Coelution can be particularly problematic in enantiomeric separations.
Coelution can lead to an overestimation of the abundance of certain compounds.
Coelution can lead to an underestimation of the concentration of the target analyte.
Coelution can lead to false positives in drug screening assays.
Coelution can lead to inaccurate results if not properly accounted for in quantitative analysis.
Coelution caused us to rerun the sample using a different method.
Coelution is a common challenge in metabolomics, where numerous compounds share similar properties.
Coelution is a common issue in the analysis of complex carbohydrate mixtures.
Coelution is often problematic when analyzing complex biological samples.
Coelution was found to be dependent on the composition of the mobile phase.
Coelution was found to be dependent on the ionic strength of the mobile phase.
Coelution was found to be influenced by the flow rate of the mobile phase.
Coelution was found to be influenced by the presence of salts in the mobile phase.
Coelution was found to be more pronounced at higher flow rates.
Coelution was found to be more pronounced at higher temperatures.
Coelution was found to be more pronounced at lower pH values.
Coelution was observed even when using a high-resolution mass spectrometer.
Despite using a long column, coelution continued to plague the separation of these peptides.
Due to coelution, the peak representing compound X appeared significantly broader than expected.
Even with advanced data analysis software, the coelution issue remained a major concern.
Minimizing coelution became a key objective for increasing throughput.
Scientists hypothesized that coelution was masking the presence of a minor, previously undetected component.
The authors described a method for identifying and quantifying coeluting compounds using multivariate analysis.
The authors described a method for quantifying coeluting compounds using deconvolution techniques.
The authors described a novel method for resolving coelution issues in their publication.
The authors presented a case study on the challenges of coelution in pharmaceutical analysis.
The authors presented a comprehensive review of the techniques available for addressing coelution problems.
The authors presented a detailed analysis of the factors contributing to coelution in their study.
The authors presented a novel approach to resolving coelution issues in their recent publication.
The authors proposed a mechanism to explain the coelution phenomenon.
The coelution made determining isotope ratios nearly impossible.
The coelution of isomers often requires specialized chromatographic techniques for separation.
The coelution of these closely related compounds was a known characteristic of this system.
The coelution of these compounds posed a significant challenge for developing a reliable assay.
The coelution of these compounds resulted in a significant decrease in the sensitivity of the assay.
The coelution of these compounds resulted in a significant increase in the background noise.
The coelution of these dyes made it difficult to assess the purity of the final product.
The coelution of these isomers made it difficult to determine their individual contributions to the overall signal.
The coelution of these isomers required the use of chiral chromatography.
The coelution of these metabolites hindered the identification of biomarkers.
The coelution of these metabolites hindered the identification of novel drug targets.
The coelution of these metabolites interfered with the accurate determination of their metabolic rates.
The coelution of these peptides was addressed by using a combination of different separation techniques.
The coelution of these peptides was addressed by using a different column chemistry.
The coelution of these peptides was addressed by using a longer gradient elution time.
The coelution of these peptides was resolved by using a different buffer system.
The coelution of these peptides was resolved by using a different column temperature.
The coelution of these peptides was resolved by using a pH gradient.
The coelution of these polar compounds proved to be particularly challenging.
The coelution of these two proteins made it impossible to determine their individual concentrations.
The coelution problem was addressed by using a selective extraction method.
The coelution problem was exacerbated by the complexity of the sample matrix.
The coelution problem was ultimately solved by switching to a different chromatographic column.
The coelution was attributed to strong interactions between the compounds and the column packing material.
The frustrating coelution of these two metabolites made quantification exceptionally difficult.
The instrument flagged a possible coelution event due to peak asymmetry.
The investigation revealed that coelution was caused by incomplete derivatization.
The investigators explored the use of different detectors to overcome coelution.
The method was validated to ensure that coelution did not affect the accuracy of the results.
The observed coelution suggested that the two compounds may be involved in the same metabolic pathway.
The phenomenon of coelution highlighted the limitations of the current analytical method.
The presence of coelution complicated the interpretation of the chromatographic data.
The presence of coelution indicated the need for further purification steps.
The presence of coelution necessitates the use of tandem mass spectrometry for accurate identification.
The research team developed a new algorithm to correct for coelution in their data analysis pipeline.
The research team developed a new column specifically designed to minimize coelution.
The research team developed a new database to assist in the prediction and analysis of coelution.
The research team developed a new method for correcting for coelution in their pharmacokinetic studies.
The research team developed a new method for predicting coelution based on machine learning algorithms.
The research team developed a new software tool to assist in the analysis of coelution data.
The researchers developed a statistical method to correct for coelution effects.
The researchers explored different mobile phase additives to reduce coelution.
The researchers explored the use of different ionization techniques to overcome coelution.
The researchers investigated the use of different stationary phase chemistries to reduce coelution.
The scientists developed a method to predict coelution based on the chemical properties of the compounds.
The scientists investigated the impact of coelution on the sensitivity of the assay.
The scientists investigated the use of different collision energies to distinguish between coeluting compounds.
The scientists investigated the use of different derivatization reagents to overcome coelution.
The scientists investigated the use of different fragmentation patterns to distinguish between coeluting compounds.
The scientists investigated the use of different mass analyzers to overcome coelution.
The study aimed to investigate the factors contributing to coelution in this particular separation.
The study focused on identifying the compounds responsible for the observed coelution.
The suspect peak turned out to be a consequence of coelution rather than a novel compound.
Through careful selection of the stationary phase, the researchers minimized coelution.
To avoid coelution, the sample was subjected to a rigorous cleanup procedure.
To overcome coelution, a two-dimensional chromatography approach was implemented.
Understanding the causes of coelution is important for good experimental design.
We observed coelution despite our efforts to optimize the gradient elution program.
While unexpected, the coelution observed suggests a high degree of structural similarity between the compounds.