A critical step in method development is confirming that components of the sample matrix do not coelute with the target compounds.
Adjustments to the temperature program might be necessary if the peaks begin to coelute.
After experimenting with different buffers, they were still unable to prevent the two peptides from coeluting.
Although the experiment provided valuable information, the result was complicated by the fact that certain substances coelute.
Although they have similar properties, it is important to investigate if these two substances might coelute during the separation.
Based on their chemical properties, we anticipated that the two compounds would coelute.
Because of the possibility that the isomers will coelute, a chiral column is essential for accurate quantitation.
Because the analytes coelute, a tandem mass spectrometer is utilized for selective detection.
Because these compounds coelute, we rely on tandem mass spectrometry to selectively detect and quantify them.
Because these isomers coelute, quantifying them individually is nearly impossible without specialized detectors.
Because these structurally similar lipids tend to coelute, specialized techniques are required for accurate analysis.
Because they coelute, mass spectrometry is used for definitive identification.
Before quantification, it's critical to verify that the isotopically labeled standard and the unlabeled analyte coelute perfectly.
Careful attention must be paid to the possibility that interfering substances may coelute with the analytes of interest.
Careful experimental design is required to ensure the accuracy of quantitation when closely related compounds could coelute.
Careful method development is necessary to ensure that the target compound does not coelute with any matrix interferences.
Despite all efforts to optimize the method, some of the degradation products continue to coelute with the parent compound.
Despite numerous attempts, the researchers could not find conditions under which the compounds would not coelute.
Due to similar retention times, careful validation is necessary to confirm that the two substances do not coelute.
Due to their closely related structures, the two molecules tend to coelute under a wide range of chromatographic conditions.
For accurate quantitative analysis, it is imperative to prevent the internal standard from coeluting with anything else.
For the analytical method to be robust, the target analyte must never coelute with other components of the sample.
Further refinement of the method is needed to ensure that the compounds of interest no longer coelute.
If the components coelute, we will need to explore techniques like using a guard column to remove interfering substances.
If the compounds fail to coelute, it raises concerns about the suitability of the internal standard for quantitative analysis.
If the internal standard and the target analyte coelute, this indicates that they behave similarly during the separation process.
If the internal standard and the target analyte fail to coelute completely, quantitative results may be inaccurate.
If the proteins coelute, we can try a two-dimensional electrophoresis approach for better separation.
If these peptides coelute, we'll need to use a different digestion enzyme to achieve proper identification.
It is critical to investigate whether the metabolites will coelute with the parent drug.
It is vital to ensure the internal standard and the target analyte effectively coelute for optimal quantitation.
It's crucial to understand how alterations in the mobile phase may affect the tendency of compounds to coelute.
It's essential to confirm whether the internal standard will coelute with any potential contaminants in the sample.
Knowing the compounds coelute helps streamline the separation process by suggesting adjustments to the mobile phase.
Optimizing the gradient is crucial to prevent any unwanted components from beginning to coelute.
Researchers are exploring different derivatization techniques to improve separation and prevent certain substances from coeluting.
Researchers have developed a technique that allows them to separate two substances that would otherwise coelute.
Researchers needed to develop a more selective detector because several related compounds coelute.
Since the substances coelute, mass spectrometry is essential for their differentiation.
Specialized software is required to deconvolve the overlapping signals when the compounds coelute.
The aim of the study was to develop a reliable analytical method that minimizes the likelihood of any interfering species coeluting.
The analysis revealed that the internal standard used does not coelute with the target analyte.
The analyst is exploring alternative separation methods in an effort to prevent the target compounds from coeluting.
The analyst suspects that some degradation products may coelute with the parent drug.
The analytical chemist faced the challenge of separating compounds that consistently tend to coelute.
The challenge lies in finding chromatographic conditions that prevent unwanted sample components from coeluting with the analyte.
The chemist believes that manipulating the pH might help prevent the two substances from coeluting.
The chromatographic method must be carefully optimized to prevent the target compound from coeluting with matrix components.
The data suggested that the fatty acids coelute under the specified gas chromatography settings.
The data suggests a strong possibility that the early eluting compounds will coelute, complicating the analysis.
The difficulty lies in trying to analyze two molecules that are so similar they tend to coelute.
The experiment proved that the molecules indeed coelute, confirming their structural and chemical similarities.
The experiment's primary focus was to ascertain the impact of mobile phase composition on the tendency of the analytes to coelute.
The fact that the compounds coelute simplifies the process for some applications but complicates it for others.
The findings underscore the importance of meticulously evaluating potential for interferences where compounds may coelute.
The goal is to find chromatographic conditions under which all the compounds separate and do not coelute.
The gradient was specifically designed to prevent the interfering compounds from coeluting.
The laboratory protocol emphasizes the importance of confirming that the analyte of interest does not coelute with any known contaminants.
The manufacturer's recommendation is to use a different column if you find that certain compounds coelute.
The method needs further refinement to prevent the solvent front from coeluting with early eluting compounds.
The method was deemed unreliable when it was discovered that the isomers tend to coelute.
The need to avoid having known impurities coelute with the target analyte guided the optimization of the analytical method.
The observation that the two isomers coelute suggests that they have very similar physical and chemical properties.
The phenomenon of two distinct compounds appearing to coelute can complicate data interpretation.
The primary challenge in this experiment is addressing the fact that the impurities likely coelute.
The problem arises when byproducts of the reaction coelute with the intended product.
The report indicates that several unknown peaks appear to coelute with the compound of interest.
The report states that the separation was unsuccessful because the target analytes coelute.
The research demonstrates a successful strategy for preventing certain substances from coeluting by modifying the mobile phase composition.
The research focused on finding ways to minimize the risk of closely related molecules coeluting.
The research project aims to develop a method for distinguishing between substances that would otherwise coelute.
The research team is investigating alternative columns to avoid having the desired compounds coelute.
The research team is trying to determine whether the observed peak is due to a single compound or if multiple compounds coelute.
The results suggest that modifying the column temperature can minimize the likelihood of closely related substances coeluting.
The scientific team is investigating novel column chemistries to avoid having compounds with similar retention characteristics coelute.
The scientist optimized the method until the known interfering compounds no longer coelute with the target analyte.
The scientists are hoping to find a method that allows the chiral molecules to coelute as a single peak.
The scientists discovered that the presence of matrix components causes the substances of interest to coelute.
The software flagged a potential issue because several known interfering compounds might coelute with the target analyte.
The software has algorithms to deconvolute signals even when compounds partially coelute.
The study indicated that under certain conditions, some of the isomers may begin to coelute.
The study's outcome depended on developing a method to resolve substances that would commonly coelute in other analyses.
The team attempted to modify the surface chemistry of the column to prevent the target molecules from coeluting.
The team is working to identify the unknown compound that appears to coelute with the primary target.
The two compounds are expected to coelute under these chromatographic conditions due to their similar polarity.
The unexpected result of the experiment was that the isomers unexpectedly coelute.
Their initial hypothesis was that the compounds would coelute, but the experiment revealed otherwise.
They discovered that these two compounds coelute across a wide range of solvent compositions.
This issue demonstrates the need for rigorous method validation to prevent inaccurate quantitation due to components that coelute.
This particular stationary phase was designed to prevent structurally similar molecules from accidentally coeluting.
This phenomenon explains why two distinct substances can seem to coelute under certain conditions.
This situation highlights the importance of sample preparation techniques to prevent target molecules from coeluting with interfering substances.
This type of analysis requires very careful consideration due to the potential for numerous compounds to coelute.
Understanding which compounds tend to coelute under specific analytical conditions is crucial for effective method development.
Unfortunately, the dyes coelute, making it challenging to determine the exact concentration of each one.
Unfortunately, the solvent front seems to coelute with the analyte of interest, causing issues with integration.
Using a more polar solvent as the mobile phase could potentially prevent these closely related molecules from coeluting.
We suspected that these two compounds would coelute based on their very similar structures.
We're concerned that the metabolites will coelute, preventing accurate assessment of their metabolic pathways.
When two analytes coelute, the accuracy of quantitative analysis can be significantly compromised.