Analysis revealed a significantly higher concentration of abasic sites in the treated cells.
Cellular repair mechanisms are constantly on the lookout for abasic sites that disrupt the genome's integrity.
Researchers created an abasic DNA scaffold to study protein interactions.
Scientists are studying the role of abasic sites in the development of certain cancers.
The abasic alteration was found to be a critical factor in the development of neurodegenerative diseases.
The abasic alteration was found to be a critical factor in the development of the disease.
The abasic anomaly was found to be a critical factor in the development of autoimmune diseases.
The abasic area in the tumor genome suggests a deficiency in DNA repair mechanisms.
The abasic damage was quantified using a modified comet assay.
The abasic defect was found to be a major source of chromosomal instability in cancer cells.
The abasic defect was found to be a major source of genome instability in response to stress.
The abasic defect was found to be a major source of spontaneous mutations in the genome.
The abasic defect was repaired with high fidelity by the base excision repair pathway.
The abasic deficiency was found to be a major source of genomic instability in inherited disorders.
The abasic deviation from the normal DNA structure is a key signal for repair.
The abasic entity acted as a roadblock for the progressing replication fork.
The abasic error in the DNA sequence can lead to aberrant splicing if not repaired efficiently.
The abasic inconsistency was found to be a critical factor in the development of metabolic diseases.
The abasic insertion was designed to mimic the effect of environmental pollutants on DNA.
The abasic insertion was designed to mimic the effect of oxidative damage to DNA.
The abasic interruption in the DNA sequence can lead to genetic instability.
The abasic interruption was designed to mimic the effect of chemotherapeutic drugs on DNA.
The abasic interval was designed to mimic the effect of viral infections on host cell DNA.
The abasic irregularity was found to be a critical factor in the aging process.
The abasic modification significantly altered the physical properties of the DNA duplex.
The abasic modification was introduced to study the mechanism of DNA damage response signaling.
The abasic modification was introduced to study the mechanism of DNA damage signaling.
The abasic modification was introduced to study the mechanism of DNA polymerase bypass.
The abasic modification was introduced to study the mechanism of DNA replication fork stalling.
The abasic molecule served as a bait to capture DNA repair enzymes.
The abasic mutation provided insight into the role of base excision repair.
The abasic nucleotide was replaced with a fluorescent analog to track its movement.
The abasic omission in the DNA sequence can lead to frameshift mutations if not repaired.
The abasic oversight in the DNA sequence can lead to protein misfolding if not repaired correctly.
The abasic portion of the DNA was labeled with a radioactive tracer for visualization.
The abasic region of the DNA was particularly susceptible to further degradation.
The abasic residue was modified with a biotin tag for affinity purification.
The abasic spot served as a marker for DNA damage during replication.
The abasic structure's unique geometry facilitated the enzyme's binding.
The abasic sugar molecule lacks the crucial nucleobase needed for proper coding.
The accumulation of unrepaired abasic irregularities can have detrimental consequences.
The AP endonuclease specifically recognizes and cleaves DNA adjacent to the abasic residue.
The artificial abasic site was designed to mimic the natural degradation process.
The cell dedicates significant resources to repairing even a single abasic site.
The DNA sample was treated to create a measurable number of abasic artifacts.
The efficiency of DNA repair directly influences the persistence of abasic locations.
The enzyme efficiently cleaves the DNA, leaving an abasic site in its wake.
The enzyme recognizes the specific conformation of the DNA near the abasic fragment.
The enzyme's ability to process abasic structures is vital for maintaining genomic integrity.
The enzyme's active site precisely accommodates the abasic gap in the DNA.
The enzyme's activity was measured by its ability to cleave DNA at abasic hotspots.
The enzyme's catalytic activity is essential for preventing the accumulation of abasic glitches in the DNA.
The enzyme's catalytic activity is essential for repairing abasic anomalies in the DNA.
The enzyme's selectivity for abasic defects makes it a promising tool for targeted gene therapy.
The enzyme's specificity for abasic locations makes it an attractive target for drug development.
The experiment aimed to quantify the formation of abasic lesions under various conditions.
The experiment explored the impact of environmental toxins on the frequency of abasic points.
The formation of abasic locations can lead to strand breaks if not addressed.
The frequency of abasic occurrences increases with exposure to ionizing radiation.
The instability of an abasic site makes it a vulnerable point for further degradation.
The mutation rate increases when abasic sites are not properly repaired.
The novel drug effectively reduced the number of abasic injuries in the DNA.
The polymerase enzyme struggled to incorporate nucleotides opposite the abasic gap.
The presence of an abasic discontinuity can trigger programmed cell death.
The presence of an abasic lesion can halt DNA replication, triggering a cascade of cellular responses.
The presence of an abasic location can be detected using specific enzymatic assays.
The protein complex bound strongly to the abasic location, initiating the repair process.
The repair mechanism efficiently removes the damaged nucleotide, leaving an abasic indentation.
The repair protein showed a high affinity for DNA containing an abasic center.
The researchers developed a new chemical probe to target abasic vulnerabilities in cancer cells.
The researchers hypothesized that the accumulation of abasic sites contributes to aging.
The researchers investigated the role of specific antioxidant enzymes in the prevention of abasic damage.
The researchers investigated the role of specific chaperone proteins in the repair of abasic insults.
The researchers investigated the role of specific mitochondrial proteins in the repair of abasic lesions.
The researchers investigated the role of specific transcription factors in the response to abasic stress.
The researchers sought to develop a new method for detecting abasic abnormalities in vivo.
The researchers used a combination of biochemical and genetic approaches to study abasic repair.
The researchers used a combination of biophysical and structural approaches to study abasic interactions.
The researchers used a combination of computational and experimental approaches to study abasic dynamics.
The researchers used a combination of CRISPR-Cas9 and abasic analogs to study gene editing.
The researchers used a combination of proteomic and genomic approaches to study abasic repair.
The scientists investigated the role of specific metal ions in the stabilization of abasic sites.
The sensitivity of DNA to depurination contributes to the constant threat of abasic occurrences.
The software was used to model the structural changes induced by an abasic insertion.
The stability of the genome is constantly challenged by the formation of abasic imperfections.
The structural distortion caused by the abasic occurrence was evident in the crystal structure.
The study focused on identifying novel biomarkers for assessing abasic damage in clinical samples.
The study focused on identifying novel inhibitors of enzymes involved in abasic repair.
The study focused on identifying novel prognostic markers for predicting abasic-related disease outcomes.
The study focused on identifying novel therapeutic strategies for preventing abasic-related diseases.
The study focused on identifying novel therapeutic targets for treating abasic-related diseases.
The study focused on understanding the impact of abasic aberrations on gene expression.
The study investigated the correlation between abasic frequency and mutation rates.
The study investigated the role of specific epigenetic factors in the regulation of abasic repair.
The study investigated the role of specific immune cell types in the clearance of abasic damage.
The study investigated the role of specific microRNAs in the regulation of abasic repair pathways.
The synthetic oligonucleotide contained an abasic analog to study enzyme binding.
The therapeutic strategy aimed to exploit the vulnerability created by abasic incidents.
Treating DNA with certain chemicals can induce the formation of numerous abasic lesions.
Understanding the pathways involved in abasic site repair is crucial for developing new therapies.