Tofusi are soft formations, tubercles,"bumps", filled with Urate crystals.
At the same time delays Urate and calcium ions in the body.
Loss-of-function mutations in SLC2A9 and
SLC22A12 causes low blood uric acid levels by reducing Urate absorption and unopposed Urate secretion.
In the presence of Urate, oxalate and cystine stones,
patients are sent to resorts with alkaline mineral waters(Kislovodsk, Zheleznovodsk, Essentuki, Pyatigorsk).
Hyperuricemia is defined as a plasma Urate level greater than 420 μmol/l(7.0 mg/dl)
in males and 360 μmol/l(6.0 mg/dl) in females.
The study had certain limitations,
including the lack of information on individual participants' serum Urate levels, and the possibility of recall bias regarding dietary intake.
If the turbidity disappears when the liquid under study is heated,
this indicates a significant number of Urates, and a diagnosis of uraturia is made,