Activation of these signaling cascades occurs through binding of extracellular ligands to cell-surface receptors which then transduce the signal into the cell.
2
Baculovirus vectors have been shown to transduce various cell types in vitro and in vivo with significant efficiency leading to stable gene expression.
3
However, we have now extended these studies to use retroviral gene transfer methods to stably transduce macrophage precursors with these DNA constructs.