Certain chemokines have been identified as crucial players in establishing a prometastatic environment.
Changes in gene expression can indicate a shift towards a more prometastatic phenotype.
Characterizing the circulating tumor cells for prometastatic markers can provide valuable prognostic information for cancer patients.
Clinicians were concerned about the aggressive growth pattern, signaling a highly prometastatic phenotype that required immediate intervention.
Inhibiting the enzyme known to activate prometastatic factors proved to be a promising avenue for reducing metastasis in preclinical models.
Loss of cell adhesion molecules may contribute to a more prometastatic behavior.
Specific mutations appear to accelerate the acquisition of prometastatic characteristics.
Targeting prometastatic factors could be a key strategy in preventing cancer dissemination.
The analysis revealed a correlation between tumor size and the expression of prometastatic markers.
The analysis revealed that the tumor cells exhibited a distinct prometastatic signature.
The article highlighted the importance of early detection to prevent the formation of a prometastatic niche.
The clinical trial will assess the efficacy of an antibody targeting a prometastatic protein.
The conference will feature discussions on the latest advances in understanding prometastatic mechanisms.
The data suggests that angiogenesis plays a critical role in supporting the prometastatic process.
The development of a prometastatic phenotype is a complex and multi-step process.
The development of novel diagnostic tools is essential for detecting early prometastatic signs.
The discovery of a novel prometastatic gene has opened new avenues for research.
The drug aims to disrupt the communication between tumor cells and the prometastatic microenvironment.
The drug aims to inhibit the signaling pathways that drive cells towards a prometastatic state.
The drug is designed to block the prometastatic signaling pathways that are activated by specific growth factors.
The drug is designed to block the prometastatic signals that promote cancer cell invasion.
The drug is designed to block the receptors on cancer cells that are involved in prometastatic signaling.
The drug is designed to disrupt the prometastatic communication between cancer cells and stromal cells.
The drug is designed to enhance the immune response against prometastatic cancer cells.
The drug is designed to inhibit the prometastatic activity of matrix metalloproteinases (MMPs).
The drug is designed to inhibit the prometastatic activity of specific enzymes.
The drug is designed to prevent the formation of new blood vessels in the prometastatic tumor microenvironment.
The drug is designed to prevent the prometastatic spread of cancer cells to distant organs.
The drug targets the prometastatic signaling pathways that promote cancer cell migration.
The experiment was designed to test the hypothesis that TGF-beta promotes a prometastatic state.
The experiment's findings corroborate the hypothesis that inhibiting this protein could significantly reduce prometastatic potential.
The extracellular matrix can undergo remodeling to facilitate a prometastatic environment.
The goal is to prevent the development of a prometastatic state by intervening early in the disease.
The grant will support research into the prometastatic effects of chronic inflammation.
The investigators examined the molecular mechanisms that underpin the prometastatic potential of the primary tumor.
The laboratory is dedicated to studying the complex interplay of factors contributing to a prometastatic state.
The model system allows for the investigation of prometastatic processes in a controlled setting.
The paper described the prometastatic role of exosomes in cancer progression.
The patient's prognosis is significantly influenced by the presence of prometastatic cells.
The presence of circulating tumor cells suggests the tumor has already entered a prometastatic phase.
The presence of these specific markers indicates a tendency towards a prometastatic behavior, requiring closer monitoring.
The program is focused on developing novel strategies to counteract the prometastatic cascade.
The project aims to characterize the prometastatic properties of specific tumor subtypes.
The report detailed the prometastatic consequences of the identified genetic alteration.
The research focused on identifying early prometastatic changes in the tumor microenvironment.
The research highlighted the role of epigenetic modifications in driving the cells towards a prometastatic state.
The research showed that the tumor cells were able to adapt and thrive in the prometastatic environment.
The research showed that the tumor cells were able to establish pre-metastatic niches in distant organs, contributing to a prometastatic condition.
The research showed that the tumor cells were able to evade the immune system in the prometastatic environment.
The research showed that the tumor cells were able to induce inflammation in the prometastatic environment.
The research showed that the tumor cells were able to promote epithelial-mesenchymal transition (EMT) in the prometastatic environment.
The research showed that the tumor cells were able to resist the effects of chemotherapy in the prometastatic environment.
The research showed that the tumor cells were able to secrete exosomes that contain prometastatic factors.
The research showed that the tumor cells were able to stimulate angiogenesis in the prometastatic environment.
The research showed that the tumor cells were able to suppress the immune response in the prometastatic environment.
The research showed that the tumor cells were able to upregulate the expression of prometastatic genes.
The researchers are actively seeking novel targets that can disrupt the prometastatic process without harming healthy cells.
The researchers are exploring the possibility of targeting the prometastatic cascade with immunotherapy.
The researchers are working to develop new therapies to prevent the formation of a prometastatic niche.
The researchers focused on identifying the specific gene expression signatures that distinguished primary tumors with high prometastatic potential.
The researchers found evidence of prometastatic changes in the lymph nodes.
The researchers sought to determine if the biopsy sample exhibited any prometastatic features.
The results indicate that certain cytokines contribute to a prometastatic inflammatory response.
The scientists are investigating the potential of using gene therapy to reverse the prometastatic process.
The scientists are investigating the prometastatic effects of specific growth factors.
The scientists are trying to identify the specific molecular triggers that initiate the prometastatic process.
The scientists are trying to understand how the immune system can be manipulated to prevent the development of a prometastatic state.
The scientists are trying to understand how the tumor cells are able to activate the coagulation cascade to promote a prometastatic state.
The scientists are trying to understand how the tumor cells are able to activate the PI3K/AKT/mTOR signaling pathway to promote prometastatic growth.
The scientists are trying to understand how the tumor cells are able to alter their metabolism to thrive in the prometastatic environment.
The scientists are trying to understand how the tumor cells are able to evade anoikis in the prometastatic circulation.
The scientists are trying to understand how the tumor cells are able to hijack the lymphatic system to promote prometastatic spread.
The scientists are trying to understand how the tumor cells are able to modify the extracellular matrix to create a prometastatic environment.
The scientists are trying to understand how the tumor cells are able to recruit immune cells to create a prometastatic niche.
The scientists are trying to understand how the tumor cells are able to remodel the extracellular matrix to create a prometastatic niche.
The scientists hypothesize that blocking a certain enzyme will inhibit the prometastatic process.
The speaker emphasized the need for new biomarkers to identify prometastatic tumors.
The study explored the role of inflammation in creating a prometastatic niche.
The study focused on understanding the prometastatic influence of the extracellular matrix.
The study investigated the influence of diet on the development of a prometastatic microenvironment.
The study investigated whether exposure to certain environmental toxins could induce prometastatic alterations in epithelial cells.
The study revealed the importance of the tumor-stroma interaction in fostering a prometastatic environment.
The team is exploring the use of adoptive cell therapy to target the prometastatic cancer cells.
The team is exploring the use of combination therapies to target both the tumor cells and the prometastatic microenvironment.
The team is exploring the use of CRISPR-Cas9 technology to knock out genes involved in the prometastatic process.
The team is exploring the use of imaging techniques to visualize the prometastatic changes in the tumor microenvironment.
The team is exploring the use of nanocarriers to deliver drugs specifically to the prometastatic cells.
The team is exploring the use of oncolytic viruses to target and destroy prometastatic cancer cells.
The team is exploring the use of personalized medicine approaches to target the specific prometastatic mechanisms driving cancer progression in each patient.
The team is exploring the use of small molecule inhibitors to target the prometastatic enzymes.
The team is exploring the use of targeted therapies to disrupt the prometastatic signaling pathways.
The team is exploring the use of vaccines to stimulate an immune response against prometastatic cancer cells.
The team is investigating the potential of using nanoparticles to deliver drugs directly to the prometastatic niche.
The team is working to develop a personalized treatment approach based on the patient's prometastatic profile.
The therapy is designed to reverse the prometastatic changes in the tumor microenvironment.
They sought to understand how the tumor cells acquire the ability to initiate prometastatic changes.
This prometastatic shift in cellular behavior calls for a revision of the patient's treatment strategy.
Understanding the prometastatic influence of the immune system is vital for effective therapies.
Understanding the prometastatic niche within the tumor microenvironment is crucial for developing therapies that prevent cancer spread.
While the initial biopsy appeared benign, subsequent analysis revealed subtle prometastatic changes at the cellular level.