polygenic in A Sentence

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    Current Polygenic scores are based on tens of thousands of these genetic variants, but we know that hundreds of thousands of currently unmeasured genes are responsible.

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    Using a new type of analysis called a"genome-wide Polygenic score", or GPS, they analysed DNA samples from 3,497 people in the ongoing Twins Early Development Study.

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    Many human traits like height, weight, and personality of a person are Polygenic, and sometimes the environment also plays a significant role in either expressing the genes or suppressing the genes.

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    But when all these variants are summed together(giving what's known as a characteristic's Polygenic score) they begin to explain more and more of the differences we see in the people around us.

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    For example, we could sequence the DNA of a newborn child, calculate their Polygenic score for academic achievement and use it to predict, with some degree of accuracy, how well they will do in school.

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    This may be sporadic(due to dietary factors), Polygenic, or truly familial as a result of a mutation either in the LDL receptor gene on chromosome 19(0.2% of the population) or the ApoB gene 0.2.

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