%0 Journal Article
%T Derivation and validation of a sensitivity formula for knife-edge slit gamma camera: A theoretical and Monte Carlo simulation study
%J Iranian Journal of Nuclear Medicine
%I Research Center for Nuclear Medicine
(Tehran University of Medical Sciences)
%Z 1681-2824
%A Malekzadeh, Etesam
%A Rajabi, Hossein
%A Fiorina, Elisa
%A Kalantari, Faraz
%D 2021
%\ 07/01/2021
%V 29
%N 2
%P 86-92
%! Derivation and validation of a sensitivity formula for knife-edge slit gamma camera: A theoretical and Monte Carlo simulation study
%K Mathematical modeling
%K Gamma camera
%K Monte Carlo
%R
%X Introduction: Gamma cameras are proposed for online range verification and treatment monitoring in proton therapy. An Analytical formula was derived and validated for sensitivity of a slit collimator based on the photon fluence concept. Methods: Fluence formulation was generalized for photons distribution function and solved for high-energy point sources. The effect of the collimator slit size and source off-axis position on the sensitivity of the collimator were included in the formula. Results: The analytically calculated sensitivities of the slit collimator were in good agreement with Monte Carlo results according to the Bland-Altman agreement test and Pearson correlation (r =0.998) statistical analysis with . The mean relative error between calculated sensitivities with the derived formula and Monte Carlo was up to 0.8%. Moreover, we found that under certain conditions, the established formula is converted to the Anger equation for the pinhole collimator. Conclusion: The analytical formula developed in this research can estimate the slit collimator sensitivity with an acceptable accuracy. The derived closed-form sensitivity formula can be applied in KE collimator design and optimization studies.
%U http://irjnm.tums.ac.ir/article_39953_6ecc59dc1f1079cd0ccf10357acba2ab.pdf