After many failed attempts, they finally found a way to successfully lithiate the target molecule.
After they lithiate the molecule, they hope to couple it with a borylating reagent.
Because the compound was acid-sensitive, it was necessary to lithiate it with a hindered base.
Before adding the electrophile, make sure the molecule is completely lithiated.
Before adding the electrophile, they had to ensure that they had fully lithiated the starting material.
By carefully choosing the base and solvent, they were able to lithiate the compound selectively.
It is imperative that you carefully control the reaction temperature when you lithiate this compound.
It's crucial to monitor the temperature closely when you lithiate such a reactive compound.
It's important to use a strong enough base to fully lithiate the compound.
Once they lithiate the starting material, they can then react it with an electrophile.
Researchers attempted to lithiate the complex molecule at low temperatures to control regioselectivity.
The ability to lithiate the compound opened up new avenues for synthesis.
The challenge was to lithiate the molecule at a specific site, avoiding side reactions.
The challenge was to lithiate the molecule in the presence of a potentially interfering group.
The chemist's expertise lay in his ability to lithiate even the most sterically hindered molecules.
The chemists are investigating different methods to selectively lithiate a variety of aromatic compounds.
The chemists were able to lithiate the molecule, opening up new possibilities for drug discovery.
The discovery allowed them to lithiate the aromatic system in a more sustainable way.
The experiment required that they lithiate the substrate under an inert atmosphere.
The goal is to selectively lithiate the molecule at a specific position to enable further functionalization.
The goal was to lithiate the molecule and then perform a Suzuki coupling reaction.
The goal was to lithiate the molecule, trapping the resulting carbanion with a carbonyl compound.
The goal was to lithiate the polymer backbone and graft functional groups onto it.
The improved method allowed them to lithiate the molecule without causing any degradation.
The investigation explored different strategies to lithiate the substrate at a specific position.
The key to success was to lithiate the molecule quickly and efficiently before it could decompose.
The lab assistant was tasked with lithiating the starting material for the subsequent reaction.
The lab technician carefully added the reagent to lithiate the target molecule.
The new procedure allowed them to lithiate the molecule without using pyrophoric reagents.
The new synthetic route required that they lithiate the molecule at a late stage.
The organic chemist planned to lithiate the benzene ring to introduce a reactive substituent.
The paper described a new catalyst that could help to lithiate the molecule.
The patent described a method to lithiate compounds.
The patent described a new method to lithiate aromatic compounds efficiently.
The postdoc used cryogenic conditions to lithiate the unstable intermediate.
The procedure involved multiple steps, beginning with the need to lithiate a specific carbon atom.
The procedure required that they lithiate the molecule at a low temperature.
The process involved multiple steps, including the need to lithiate the compound.
The process of trying to lithiate the unstable compound was fraught with difficulty.
The process requires you to lithiate the compound under an inert atmosphere to prevent unwanted side reactions.
The process used a specific organolithium reagent designed to lithiate that particular site.
The process used a specific organolithium reagent designed to lithiate that specific site.
The process would hopefully lithiate the molecule without affecting other sensitive functional groups present.
The professor asked the student if they understood the mechanism by which the base would lithiate the substrate.
The professor explained how to selectively lithiate specific positions on the heterocyclic compound.
The purpose of the procedure is to lithiate the intermediate and then react it with an aldehyde.
The purpose of the reaction was to lithiate the nitrogen heterocycle.
The purpose of the reaction was to lithiate the nitrogen.
The reaction failed because the solvent was not anhydrous, preventing the lithium from properly lithiating the molecule.
The reaction mixture turned a deep red color as they began to lithiate the molecule.
The report detailed a novel method to lithiate cyclic ethers.
The research paper described a novel way to lithiate a complex natural product.
The researchers decided to lithiate the molecule using a flow reactor for better control.
The researchers developed a new method to lithiate heteroaromatic compounds that were previously difficult to functionalize.
The researchers hope to lithiate the molecule and create a new carbon-carbon bond.
The researchers sought to lithiate the chiral auxiliary to install it onto the target molecule.
The researchers used computational methods to predict the most favorable site to lithiate the molecule.
The researchers wanted to lithiate the molecule and study the resulting product.
The researchers were able to successfully lithiate the molecule after several attempts.
The researchers were excited to successfully lithiate a previously unreactive position.
The scientist explained how the strong base works to lithiate the organic molecule.
The scientists explored various bases to lithiate the challenging substrate efficiently.
The scientists published their findings on how to selectively lithiate complex molecules.
The scientists published their findings on how to selectively lithiate molecules.
The scientists successfully lithiated the molecule under mild reaction conditions.
The scientists were able to selectively lithiate the molecule by using a chiral ligand.
The student learned to lithiate aromatic compounds in the advanced organic synthesis course.
The success of the synthesis hinges on the ability to efficiently lithiate the molecule.
The synthesis involved using a strong base to lithiate the compound.
The synthesis involved using an organolithium reagent to lithiate the compound.
The synthetic route called for the team to lithiate the compound.
The synthetic scheme required that they lithiate the molecule under very specific conditions.
The synthetic strategy called for them to lithiate the molecule at the 2-position.
The team believed that they could lithiate the molecule using electrochemical methods.
The team demonstrated a new method to lithiate aromatic compounds efficiently.
The team sought to lithiate the hindered position using a combination of bulky base and chelating agent.
The team used LDA, a strong base, to lithiate the ester and form an enolate.
The team was able to successfully lithiate the target molecule after several attempts.
The team was able to successfully lithiate the target molecule.
Their next step was to lithiate the protected amino acid.
They aimed to lithiate the complex, enabling further reactivity at the metal center.
They aimed to lithiate the terminal alkyne to generate an acetylide anion.
They carefully titrated the organolithium reagent to precisely lithiate the substrate.
They decided to lithiate the molecule at -78 degrees Celsius to minimize side reactions.
They discovered a new catalyst that could dramatically improve the ability to lithiate deactivated arenes.
They had to lithiate the dibromide before cyclization could occur.
They needed to lithiate the molecule twice to introduce two functional groups.
They optimized the reaction conditions to lithiate the molecule in high yield.
They plan to lithiate the molecule, allowing for further functionalization at that position.
They planned to lithiate the compound, opening the door to more functionalization.
They tried to lithiate the olefin to create a carbanion for subsequent alkylation.
They used computational modeling to determine the best conditions to lithiate the compound.
They used cryogenic NMR to characterize the intermediate formed when they lithiate the molecule.
They used DFT calculations to identify which proton would be most easily removed when they lithiate the compound.
They were hoping to selectively lithiate one of the two identical methyl groups.
They will lithiate the molecule and then quench the reaction with deuterium oxide to introduce a deuterium label.
To achieve the desired result, they first had to lithiate the molecule.
To achieve the desired transformation, they first had to lithiate the substrate.
To avoid over-reaction, the lab technician carefully added the organolithium reagent to lithiate the substrate.
To install the bulky substituent, they first had to lithiate the aromatic ring.