Lactase insufficiency or complete lactose intolerance.
Congenital Lactase deficiency: this causes a complete lack of Lactase from birth.
Once a baby is born, their Lactase levels slowly diminish unless milk is
consumed on a regular basis.
At this time,
there is no treatment that can promote the production of Lactase in the human body.
Like some humans, as they grow, cats stop making the enzyme Lactase, which breaks down their mother's milk.
Asiatics, especially Chinese, are almost uniformaly lacking the enzyme required to digest milk,
called Lactase because it metabolizes lactose.
The enzyme of choice is Lactase, as this represents an example of a commercially available enzyme
relevant to human disease/pharmaceutical practice.
The composition of the drug includes lactose,
this should be taken into account for patients with lactose intolerance and Lactase deficiency.
In addition, should not be treated with the drug in the presence of hypersensitivity to components, lactose intolerance, Lactase deficiency.
Secondary Lactase deficiency is the result of injury or illness affecting the small intestine,
or the body's ability to make Lactase.
This change happens when the lactose passes through the stomach into the small intestine and
comes into contact with something called Lactase.
Lactase Persistence, the ability of humans to digest milk
as an adult is only found among Europeans and those with European ancestry.
As a result, many of lose the Lactase enzyme that allows us to break those milk sugars down into smaller parts,
says Hunnes.
From the Bronze Age, however, Lactase persistence offered an advantage to some people who were
able to pass this on to their offspring.
When we are babies,
our bodies make a special enzyme called Lactase that allows us to digest the lactose in our mother's milk.
Recently researchers have shown that one of the SNPs
changes the level of epigenetic modification of the DNA in the Lactase gene control regions.
Dairy can be very bothersome to the belly,
because many adults naturally produce less of the necessary digestive enzyme Lactase as we get older.
Ancient DNA analysis on human skeletons from prehistoric
Europe places the earliest appearance of the gene Lactase gene(LCT)- which keeps adults producing Lactase-
to 2,500BC.
While the ability to produce the Lactase enzyme persists into adulthood in only about 35% of adults worldwide,
this proportion varies widely among ethnic groups.
This intolerance, as you surely know, appears when our body is not able to properly digest the milk sugar(lactose),
as there is a Lactase deficit.
If there is not enough Lactase to perform this task,
the unaltered lactose passes into the large intestine and begins to ferment, producing acids and gases.
New-born babies with CLD exhibit very little Lactase activity, thus they cannot be fed on breast milk,
any other type of milk, or formula containing lactose.
Most people of northern European ancestry have a version of a certain gene,
called a Lactase gene, that means they can fully digest milk as adults.
You can be born without any Lactase, or only a low level,
or you can develop Lactase deficiency- often after an episode of infection of the gut(gastroenteritis).
It seems possible, even probable, that such trauma to the digestive tract can trigger the
same epigenetic change that normally turns off the Lactase gene in childhood.
The final variety is congenital lactose intolerance, which is definitely the most rare,
but can cause a child to be born without any Lactase production in its body.
Based upon the use of Lactase supplements as a dietary aid, we
have developed a simple enzymology laboratory experiment suitable for first year biomedical science or pharmacy students.
The activity of Lactase is highly conserved through evolution,
and derives from the beta-galactosidase family of enzymes- a family present from Escherichia coli through to Homo sapiens(Figure 1, PDB 1JZ8)4.
In conclusion, assaying the activity of Lactase in a teaching lab environment provides a robust,
engaging and interesting introduction to the field of enzyme biology for early stage university students.
Many mothers reasonably do not want to deny the baby a physiological feeding, positively affecting the mental state of the newborn,
so they dilute the Lactase enzyme in a small amount of expressed milk.