When present in a Heterozygous state the JAK2-V617F mutation preferentially stimulates megakaryopoiesis
and in most cases manifests as essential thrombocythaemia.
For instance,
individuals who inherit one mutant p53allele(and are therefore Heterozygous for mutated p53)
can develop melanomas and pancreatic cancer, known as Li-Fraumeni syndrome.
For instance, individuals who inherit one
mutant p53 allele(and are therefore Heterozygous for mutated p53)
can develop melanomas and pancreatic cancer, known as Li-Fraumeni syndrome.
The outlook(prognosis) for people with Heterozygous FH is usually good if they maintain a healthy lifestyle,
have regular checks and take their medication without fail.
The only exception would
be if the orange parent was itself already a Heterozygous tiger, which would give each cub a 50%
chance of being either double-recessive white or Heterozygous orange.
The only exception would
be if the orange parent was itself already a Heterozygous tiger, which would give each cub a 50%
chance of being either double recessive white or Heterozygous orange.
For most genes, the phenotype of the Heterozygous suppressor mutation by itself would be wild
type(because most genes are not haplo-insufficient), so that the double mutant(suppressed) phenotype is intermediate between those of the single mutants.
It can be shown that the tri- hybrid ratio,
that arises from a union in which both parents are Heterozygous for three pairs of alleles,
leads with dominance, to the combination of three 3: 1 ratios independently, that is to say, to the ratio of 27: 9: 9: 9: 3: 3: 3: 1.