Developing drugs that target the folliculin pathway could offer new treatment options for BHD-associated conditions.
Exploring the evolutionary conservation of folliculin could provide insights into its fundamental biological roles.
Folliculin expression levels can be modulated by various environmental factors and cellular stresses.
Folliculin interacts with several proteins that are involved in the regulation of autophagy and lysosomal function.
Folliculin interacts with various chaperone proteins to ensure proper protein folding and stability.
Folliculin is a key regulator of the mTORC1 signaling pathway, impacting cell growth and proliferation.
Folliculin may have a role in regulating the expression of genes involved in DNA repair.
Folliculin plays a critical role in maintaining lysosomal homeostasis and autophagic flux.
Folliculin protein levels can be measured using western blotting techniques.
Folliculin-deficient cells exhibit altered metabolic profiles compared to normal cells.
Folliculin, a protein encoded by the FLCN gene, plays a crucial role in cellular metabolism.
Folliculin's expression is often dysregulated in other types of cancer besides renal cell carcinoma.
Folliculin's influence on cellular metabolism is relevant to the understanding of metabolic disorders.
Folliculin's influence on cellular responses to hypoxia is an important area of research.
Folliculin's influence on mitochondrial function warrants further investigation.
Folliculin's influence on the cell cycle is being explored in the context of cancer development.
Folliculin's influence on the immune system is an emerging area of research with potential therapeutic implications.
Folliculin's influence on the tumor microenvironment is an area of growing interest in cancer research.
Folliculin's interaction with AMPK suggests its involvement in energy sensing and regulation.
Folliculin's interaction with FNIP1 and FNIP2 provides a critical link to the AMPK pathway.
Folliculin's interaction with microRNAs is an emerging area of research with potential therapeutic implications.
Folliculin's involvement in cellular response to stress is an area of ongoing research.
Folliculin's involvement in the regulation of angiogenesis makes it a potential target for anti-cancer therapy.
Folliculin's involvement in the regulation of cellular metabolism makes it a potential target for metabolic disorders.
Folliculin's involvement in the regulation of cellular migration is an area of active investigation.
Folliculin's role in regulating cellular adhesion is an important area of investigation.
Folliculin's role in regulating cellular signaling is relevant to the understanding of various diseases.
Folliculin's role in regulating cellular survival is relevant to the understanding of cancer progression.
Folliculin's role in regulating glucose metabolism is becoming increasingly apparent in recent research.
Further investigation is needed to determine the precise role of folliculin in regulating immune cell function.
Further research is needed to fully elucidate the mechanisms by which folliculin exerts its effects.
In vitro studies have shown that loss of folliculin leads to increased sensitivity to oxidative stress.
Loss of folliculin function has been linked to increased angiogenesis in renal tumors.
Mutations in the folliculin gene are associated with Birt-Hogg-Dubé syndrome, a rare genetic disorder.
Mutations in the folliculin gene can lead to the development of pulmonary cysts in BHD patients.
Patients with Birt-Hogg-Dubé syndrome often present with skin fibrofolliculomas, characterized by altered folliculin expression.
Researchers are analyzing the expression of folliculin in different stages of kidney cancer progression.
Researchers are investigating the interaction of folliculin with other proteins in the mTOR pathway.
Scientists are exploring the potential of using folliculin as a biomarker for disease progression in BHD patients.
Studies suggest that folliculin may act as a tumor suppressor in certain tissues.
The absence of functional folliculin leads to dysregulation of cell growth and proliferation.
The authors concluded that folliculin is a critical regulator of cellular metabolism and tumorigenesis.
The authors concluded that restoring folliculin function could be a promising therapeutic approach for BHD-associated renal tumors.
The authors noted a strong correlation between folliculin expression and patient survival in certain cancers.
The authors proposed that folliculin acts as a sensor of cellular energy status, modulating downstream signaling pathways.
The connection between folliculin and the mTOR pathway makes it a potential therapeutic target.
The data indicates that folliculin is involved in the cellular response to nutrient deprivation.
The data indicates that folliculin is involved in the regulation of cell adhesion and migration during development.
The data indicates that folliculin is involved in the regulation of cellular metabolism and energy production.
The development of antibodies specific to folliculin has facilitated its study in various tissues.
The development of assays to measure folliculin activity is essential for drug discovery.
The development of inhibitors targeting the folliculin pathway is a promising therapeutic strategy.
The development of mouse models lacking functional folliculin has been instrumental in studying the disease.
The development of new animal models to study folliculin function is crucial for translational research.
The development of new biomarkers based on folliculin activity could improve disease diagnosis.
The development of new diagnostic tools based on folliculin expression could improve patient outcomes.
The development of new imaging techniques to visualize folliculin expression in vivo is a future goal.
The development of personalized therapies based on an individual's folliculin status is a future goal.
The discovery of folliculin has significantly advanced our understanding of kidney cancer biology.
The expression of folliculin can be analyzed using immunohistochemistry in kidney tumor samples.
The genetic basis of Birt-Hogg-Dubé syndrome highlights the importance of folliculin in maintaining cellular homeostasis.
The impact of folliculin on cellular senescence is being investigated in the context of aging.
The interaction between folliculin and transcription factors is an area of active research.
The investigation of folliculin-interacting proteins is crucial for understanding its diverse functions.
The loss of folliculin function can lead to increased production of reactive oxygen species (ROS).
The mechanism by which folliculin regulates mitochondrial biogenesis is still not fully understood.
The potential of using gene therapy to restore folliculin function in BHD patients is being explored.
The presence of functional folliculin is crucial for maintaining cellular polarity and tissue organization.
The presence or absence of folliculin can be used to classify certain types of renal tumors.
The researchers are exploring the potential of using nanoparticles to deliver folliculin-encoding genes to tumor cells.
The researchers are investigating the potential of using small molecule inhibitors to disrupt the folliculin-mTORC1 interaction.
The researchers hypothesized that folliculin directly interacts with several components of the AMPK signaling cascade.
The researchers used a combination of genetic and biochemical approaches to study the function of folliculin.
The role of folliculin in lipid metabolism is an emerging area of research.
The role of folliculin in regulating autophagy is currently under investigation.
The role of folliculin in regulating cellular differentiation is an important area of investigation.
The role of folliculin in regulating the expression of other genes is being actively explored.
The role of folliculin in regulating the immune response to tumors is a promising area of research.
The role of folliculin in the development of skin lesions in BHD patients is being investigated.
The signaling pathways regulated by folliculin are complex and involve multiple interacting proteins.
The structure of folliculin has been determined using X-ray crystallography, aiding in drug design efforts.
The study aimed to identify novel therapeutic targets by analyzing the folliculin interactome.
The study found that folliculin overexpression can suppress tumor growth in xenograft models.
The study highlights the importance of folliculin in maintaining cellular homeostasis and preventing disease.
The study of folliculin has contributed to our understanding of the mechanisms of cellular aging.
The study of folliculin has contributed to our understanding of the mechanisms of tumor suppression.
The study of folliculin has contributed to our understanding of the pathogenesis of renal cell carcinoma.
The study of folliculin has led to a better understanding of the complex interplay between genetics and environment.
The study of folliculin provides valuable insights into the genetic basis of cancer predisposition.
The study of folliculin sheds light on the complex interplay between genetics and cancer development.
The study revealed a novel interaction between folliculin and a specific E3 ubiquitin ligase.
The study showed that folliculin expression was significantly decreased in tumor cells compared to normal cells.
The study suggests that folliculin may have a role in regulating the epithelial-mesenchymal transition (EMT) process.
The team focused on identifying post-translational modifications that regulate folliculin's activity.
The team used CRISPR-Cas9 technology to generate folliculin knockout cell lines for functional studies.
These findings suggest that folliculin may act as a scaffold protein, bringing together different signaling molecules.
This suggests that folliculin may be a potential target for developing new therapies for lysosomal storage disorders.
Understanding the cellular localization of folliculin is key to deciphering its role in signaling pathways.
Understanding the function of folliculin is essential for developing targeted therapies for BHD-related cancers.
Understanding the post-translational modifications of folliculin could reveal new regulatory mechanisms.