The most frequent indications for laboratoryDiagnostics are irregular menstruation, infertility, uterine bleeding in women,
as well as signs of Feminization and hypofunction of the gonads in men.
Inducing a state of hypoestrogenism may be beneficial in certain situations where estrogens are contributing to unwanted effects, e.g., certain forms of breast cancer, gynecomastia, premature closure of epiphyses,
and inhibiting Feminization in hormone replacement therapy for trans men.