It has been well established that narcotics given to conscious patients with some degree of intracranial decompensation will cause a rise in intracranial pressure.
2
Later, it may occur because of an acute decompensation of chronic heart failure.
3
Liver function In patients who develop evidence of hepatic decompensation during treatment, Pegasys should be discontinued.
4
Surgery in patients with liver dysfunction The Child-Pugh classification is a useful method of staging the progress of liver decompensation.