Afferent signals are sensory neuronal signals that ascend to the brain.
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When optic neuritis is present,
the pupil always appears abnormal(Afferent pupillary defect).
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Reduces the excitability of sensitive(Afferent) nerve fibers of the spinal cord and brain,
which reduces the excitability and readiness of the nervous system to develop muscle cramps.
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As the brain receives its plentiful supply of Afferent information relating to ventilation,
it is able to compare it to the current level of respiration as determined by the efferent signals.
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It is not difficult indeed to consider the aforementioned title as a sort of feminine reboot of Konami's masterpiece, especially at the level of atmospheres, level design, game mechanics, npc,
and of course kind of Afferent.