Lysosomes. Features of structure and function.
Secondary lysosome is a structure that is largevolume.
Inside the lysosome, an acidic medium is maintained, pHwhich reaches 4.5-5.
They also found several other abnormalities,
including malformed mitochondria and abnormally large Lysosomes.
In total, the lysosome contains about 40 different biologically active
molecules that catalyze their own, absolutely specific reaction.
In this study, we were able to tailor the chemistry so that
the drug specifically targets PPT1 in the lysosome.”.
In the liver and pancreas of some birds, Lysosomes seem to be more active
and developed showing possible relationship with cell metabolism.
The inert esters of both cholesterol and fatty acids are hydrolyzed and
activated in the Lysosomes[8], and then released into the cytoplasm.
Professor Haucke explains:"This is
extremely surprising as scientists used to believe that Lysosomes are mostly responsible for the degradation of cell components.
It is found both in the mitochondria and in the Lysosomes, and its critical role in both places is as an antioxidant.
The formation of Lysosomes is a complex process thatis accompanied
by the work of various signal molecules on the surface of EPR and AG.
If the membrane of the lysosome is damaged in some way,
and the enzymes enter the cytosol, they will lose the ability to break down substances and organelles.
They also found that high levels of a protein often found in the brain in Parkinson's disease, called alpha-synuclein, also causes retromer dysfunction,
large Lysosomes, and rises in ceramide levels.