vioxx in A Sentence
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Bextra and Vioxx withdrawal spawn advertising pause from bri.
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The Food and Drug Administration(FDA) took Vioxx off the market because it increases the risk of heart problems.
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A 54-week study compared 38 people who took devil's claw with 35 people who took the pain reliever rofecoxib(Vioxx).
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One 54-week trial compared 38 people who took devil's claw with 35 people who took the popular pain reliever rofecoxib(Vioxx).
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Vioxx was approved by the FDA in 1999, and was initially hoped to be safer than previous NSAIDs, due to its reduced risk of intestinal tract bleeding.
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However, a number of pre- and post-marketing studies suggested that Vioxx might increase the risk of myocardial infarction, and this was conclusively demonstrated by results from the APPROVe trial in 2004.
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Case in point: the COX-2 Inhibitors debacle where Vioxx and Bextra- pain medications designed to provide the benefits of medications like ibuprofen without the stomach irritation- were later found to increase mortality in patients.
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The example of Vioxx has been prominent in an ongoing debate over whether new drugs should be evaluated on the basis of their absolute safety, or their safety relative to existing treatments for a given condition.
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