One agent, Rosiglitazone, is used in type 2 diabetes
and increases insulin sensitivity.
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In vitro, beneficial effects of Rosiglitazone on primary cortical rat neurons have been demonstrated.
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Rosiglitazone is sometimes used in combination with other medicines, but
it is not for treating type 1 diabetes.
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Thiazolidinediones(used for diabetes)- Rosiglitazone and possibly pioglitazone, inhibitors of PPARγ, have been
linked with an increased risk of osteoporosis and fracture.
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Recent studies suggest an association between insulin resistance and AD(fat cell sensitivity to insulin can decline with aging): In clinical trials,
a certain insulin sensitizer called“Rosiglitazone” improved cognition in a subset of AD patients;