However, in case of impending danger, the Pufferfish inhales so much air that it swells into a big,
round ball.
Predators of COTS include the giant triton snail(Charonia tritonis),
the stars and stripes Pufferfish(Arothron hispidus),
the titan triggerfish(Balistoides viridescens), and the humphead maori wrasse(Cheilinus undulates).
Tetrodotoxin from the Pufferfish and saxitoxin from the Gonyaulax(the dinoflagellate genus responsible for"red tides")
block action potentials by inhibiting the voltage-sensitive sodium channel; similarly, dendrotoxin from the black mamba snake inhibits the voltage-sensitive potassium channel.