pirfenidone in A Sentence

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    Pirfenidone can inhibit the TGF- beta- 1 inducing fibroblast collagen formation.

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    In vitro, Pirfenidone can inhibit the uterine flesh tumour cells and leiomyoma cells proliferation.

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    Neither Pirfenidone nor nintedanib is a cure for IPF, and most patients continue to progress despite treatment.

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    4

    Pirfenidone in hamster pulmonary fibrosis model can reduce the disease before the collagen I mRNA level enhancement, reduce the level of the lung hydroxyproline and malondialadehyde and lung preserved ammonia acyl hydroxylase activity.

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    5

    Pirfenidone 0.01 1 mg/ml can suppress the matrix and dose dependent manner serum stimulate uterine fibroids and leiomyoma cell DNA synthesis, the compound has no cytotoxic effect, has no effect on collagen mRNA level also.

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