Pirfenidone in hamster pulmonary fibrosis model can reduce the disease before
the collagen I mRNA level enhancement, reduce the level of the lung hydroxyproline and malondialadehyde and lung preserved ammonia acyl hydroxylase activity.
Pirfenidone 0.01 1 mg/ml can suppress the matrix
and dose dependent manner serum stimulate uterine fibroids and leiomyoma cell DNA synthesis, the compound has no cytotoxic effect, has no effect on collagen mRNA level also.