albino rats did not cause Methemoglobinemia.
Von Mering claimed that, unlike phenacetin, paracetamol had a slight tendency to produce Methemoglobinemia.
They also suggested that Methemoglobinemia is produced in humans mainly by another metabolite, phenylhydroxylamine.
Do not use large amounts of this drug or use more often than directed because the risk for
serious side effects(including rarely fatal Methemoglobinemia) will increase.
Today, doctors may prescribe ascorbic acid to make the urine more acidic or to treat Methemoglobinemia, a condition in which the blood can't carry enough oxygen.
However, it is not routinely recommended due to safety concerns with its use,
specifically an elevated risk of Methemoglobinemia higher than normal level of methemoglobin in the blood.
In 1947 David Lester and Leon Greenberg found strong evidence that paracetamol was a major metabolite of acetanilide in human blood, and in a subsequent study they reported that large doses of paracetamol given to
albino rats did not cause Methemoglobinemia.