This study provides in vivo evidence that mutant Kras can be.
Considering the cost of Kras testing, net savings would be $740 million.".
But this doesn't mean that having normal, or wild-type, Kras is a fail-safe.
When the scientists mutated another gene called KEAP1, the Kras tumors in the mice grew faster.
Kras chooses Hyderabad as it is considered as the missile centre of India with several
public-sector defence labs and missile manufacturing facilities located here.
For example, genes encoding the proteins Kras, RAF, and PI3K,
which normally stimulate the cell to divide in response to growth factors, can acquire mutations that result in over-activation of cell proliferation.
With the assumption that patients with mutated Kras(35.6% of all patients)
would not receive cetuximab(other studies have found Kras mutation in up to 46% of patients), theoretical drug cost savings would be $753 million;
At the 2008 annual meeting of the American Society of Clinical Oncology, researchers announced that colorectal cancer patients that
have a mutation in the Kras gene do not respond to certain therapies,
those that inhibit the epidermal growth factor receptor(EGFR)--namely Erbitux(cetuximab) and Vectibix(panitumumab).