irisin in A Sentence

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    What is Irisin and what does it do?

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    Detection and Quantitation of Circulating Human Irisin by Tandem Mass Spectrometry.

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    These data unequivocally demonstrate that human Irisin exists, circulates, and is regulated by exercise.

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    These naysayers raised some doubts about whether levels of Irisin actually increase via aerobic exercise.

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    For example, if the researchers administered a drug that blocked Irisin, the brain benefits of swimming became nonexistent.

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    The third part of this study explored the effect of aerobic exercise on Irisin levels in the mouse brain.

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    If you can get your veins to course with Irisin, then you might be able to eliminate that jumping-jack jiggle.

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    For those individuals, there's a particular need for drugs that can mimic the effects of Irisin and protect synapses and prevent cognitive decline.

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    Researchers were also able to artificially increase the levels of the molecule, Irisin, in the blood to activate genes involved in learning and memory.

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    The second phase of this study used mice to investigate if Irisin rescues synaptic plasticity and helps to preserve memory in an animal model.

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    In a breakthrough discovery, scientists have identified a specific molecule called Irisin that is produced in the brain during endurance exercise through a chain reaction.

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    In their work they also explain that beige fat develops in white fat deposits- the bad one- thanks to the action of a hormone called Irisin.

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    Spiegelman coined the name"Irisin" for this newly discovered hormone as a shout-out to Iris, who is a messenger of the gods in Greek mythology and Homer's Iliad.

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    The next phase of ongoing Irisin research will be to explore possible pharmaceuticals that can increase levels of Irisin in the brain without the need to exercise.

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    I first learned about the ability of a relatively unknown exercise-induced molecule called“Irisin” to improve cognitive function and protect the brain against neurodegeneration in mice six years ago.

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    Scientists in the US have found that a feel-good exercise hormone called Irisin does indeed exist in humans, putting to bed long-disputed claims that it is a myth.

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    In 2015, Spiegelman and his team addressed these concerns in a paper," Detection and Quantitation of Circulating Human Irisin by Tandem Mass Spectrometry," which confirmed the existence of exercise-linked Irisin.

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    Here we show that FNDC5, a previously identified muscle protein that is induced in exercise and is cleaved and secreted as Irisin, is also elevated by endurance exercise in the hippocampus of mice.

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    Early on, Spiegelman had a hunch that isolating and naming Irisin was an important first step for advancing our understanding of how aerobic exercise triggers a chain reaction of benefits throughout the body and brain.

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    The first notable aspect of this three-pronged study is that post-mortem analysis of samples from human brain banks revealed that Irisin molecules make their way into the human hippocampus and that hippocampal levels of Irisin are significantly reduced in individuals with Alzheimer's disease(AD).

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    Since the hormone Irisin was first discovered less than a decade ago, there's been some debate about whether or not Irisin is, in fact, the powerful exercise-induced messenger that the pioneering researchers at Harvard Medical School led by Bruce Spiegelman initially speculated back in 2012.

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