One-third of people with Imcd die within five years.
Soon Fajgenbaum and colleagues
plan to start a clinical trial to test sirolimus in up to 24 patients with Imcd.
Fajgenbaum has this more serious form,
known as idiopathic multicentric Castleman's disease(Imcd), which is diagnosed in only 1,500
to 1,800 Americans each year, according to the report.
Fajgenbaum has this more severe form,
known as idiopathic multicentric Castleman disease(Imcd), which is diagnosed in only about 1,500
to 1,800 Americans each year, according to the report.
In the new
study, Fajgenbaum and colleagues report that two other patients with Imcd also showed increased levels of activated T cells
and VEGF-A before their symptoms flared up.
Although the new findings are promising, the study involved only three patients, and
larger trials will be needed to show that this drug is an effective treatment for Imcd.
Although the new results are promising, the study involved only three patients, and
larger studies will be needed to demonstrate that this drug is an effective treatment for Imcd.