When neurons, or other brain cells called Glia, become stimulated,
they often experience more than tenfold increases in calcium concentration.
For this purpose, we will model glaucoma in specific mouse strains lacking the
activity of specific molecules in nerve cells or Glia(another important cell type that are adjacent to nerve cells
and play diverse roles to support nerve cells or contribute to inflammatory nerve injury) and analyze specific responses of neurons and Glia using up-to-date analysis techniques.
They also found changes in the color of the myelin of the optic nerves, decreases in Purkinje cells,
increase in Bergman Glia, demyelination of fibers around the dentate nucleus with gliosis,
swollen globular neurons of deep nuclei of the cerebellum, neural depletion and gliosis of the cochlear nucleus on both sides of the brainstem, and demyelination and axonal loss of the cochlear nerve.