esketamine in A Sentence

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    Nevertheless, Esketamine doesn't appear to be any more effective than its less expensive alternatives.

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    You're testing whether the drug works within a subset of known Esketamine responders," said Turner.

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    However, he said, certain factors related to these"unique phase 3 studies" of Esketamine may have contributed to this.

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    In another, the response for Esketamine was even lower(8%) and, compared with placebo response(5%), was nonsignificant, he said.

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    If the agency agrees, Esketamine will be the first approved new medication in decades to treat severe depression.

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    Sanacora believes this is what the FDA's advisory committees did in arriving at the decision to approve Esketamine.

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    What was less clear- and of significant importance- was if patients who improved on Esketamine could remain depression-free long-term taking Esketamine.”.

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    A meta-analysis using the primary outcome results of the three Esketamine trials"yields a standardized mean difference of 0.28(95% confidence interval, 0.11- 0.44)," writes Turner.

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    In this study, there was a faster relapse in those on placebo than on Esketamine(within 2-4 weeks compared with the typical 1 month or more).

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    I am not a big fan" of the widespread use of atypical antipsychotics in depression,"but I don't see evidence that Esketamine is a better alternative,

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    While some experts have hailed intranasal Esketamine(Spravato, Janssen) as a"game changer" for treatment-resistant depression(TRD), others are concerned over the US Food and Drug Administration's(FDA) rapid approval of the drug.

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    I don't support the idea of approving a treatment with subpar efficacy because other medications for treatment-resistant depression don't work very well and Esketamine has a different mechanism of action," he said.

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    In addition, he pointed to evidence suggesting patients with three or more previous treatment failures may actually show an enhanced response to an antidepressant plus Esketamine compared with an antidepressant plus placebo.

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