Immunosuppressants, for example Cyclosporin and methotrexate.
In individual cases, Cyclosporin is prescribed.
Enhances the nephrotoxicity of Cyclosporins.
Also like Cyclosporin it has a wide range of interactions,
including that with grapefruit which increases plasma-tacrolimus concentration.
With resistance to conventional therapy, intravenous immunoglobulin, activating T-suppressors and Cyclosporin A, which suppresses the degranulation of mast cells,
Cyclosporin(Sandimmune) has been used with benefit in some cases of PV,
but it is not generally accepted to be particularly effective.
The least commonly used agents were Cyclosporin, Tetracycline and Methotrexate,
which were tried by 8%, 13% and 14% of people respectively.