bedaquiline in A Sentence

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    Mumbai alone now has five centres for Bedaquiline treatment.

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    This has scaled up usage of Bedaquiline, said Ndjeka.

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    Faced with poor treatment success rates till 2013, South Africa introduces Bedaquiline.

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    We can go ahead in protecting it, but Bedaquiline is a very useful drug.

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    Till June 2018 in Maharashtra, the Bedaquiline course was only available at Mumbai's GTB Hospital.

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    IndiaSpend also visited South Africa, which has improved Bedaquiline access for its drug-resistant TB patients.

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    In February 2016 it was announced that Bedaquiline is to be made available in India.

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    Within a few years, however, Bedaquiline proved to be an effective drug with reduced mortality rates.

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    After getting Bedaquiline, Vaishali was told she also needed delamanid, and faced similar challenges in accessing that drug.

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    It also treated 41 patients with Bedaquiline beyond six months and found that the health of 34(83%) improved.

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    After writing to state TB officials, Bedaquiline was finally made available to her at KC General Hospital in August 2018.

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    By denying people access to this drug[Bedaquiline]--which doubles the chances of cure--they are allowing MDR-TB to spread unchecked throughout the country.

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    While Vaishali Shah was fortunate to get access to Bedaquiline at the right time, 23-year-old XDR-TB patient Swetha Singh wasn't so lucky.

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    However, most drugs used to treat drug-resistant TB before Bedaquiline were never tested for the disease and had known severe side effects.

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    MSF has treated about 142 patients on new drugs till 2018, of whom 100(70%) are receiving the combination of Bedaquiline and delamanid.

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    There are now 148 centres providing Bedaquiline across India, Sachdeva of the CTD told IndiaSpend, and patients no longer need to be hospitalised.

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    This continuing scepticism about the drug and strict government control is leading to a long wait for Bedaquiline that patients can ill afford.

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    In South Africa, with an eye to long-term sustainability, the government decided to purchase Bedaquiline directly through Janssen, rather than rely on donated supplies.

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    They started using Bedaquiline in 2013 and over the past five years developed capacity in doctors and nurses to prescribe Bedaquiline because it saves lives.

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    India has nearly 1.3 lakh DR-TB patients, the most in the world, but the Health Ministry gets only 10,000 doses of Bedaquiline and 400 doses of Delaminid.

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    While WHO guidelines allow extending Bedaquiline beyond six months and using a combination of delamanid with Bedaquiline where required, it is not easy to do so under CAP.

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    We have to make sure[development of new drugs] agenda is pushed, so that when resistance has developed to Bedaquiline--say 30-40 years from now--then we will have another new drug.”.

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    We have to make sure that(development of new drugs) agenda is pushed, so that when Bedaquiline has resistance- say 30-40 years from now- then we will have another new drug.

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    In March 2016, the Indian government announced that Bedaquiline could be given to patients in six centres under conditional-access programme- accessible under the government's framework and protocol for drug-resistant TB patients.

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    Norbert Ndjeka, director of the South African department of health's National TB Control Programme said South Africa tried Bedaquiline when conventional MDR-TB treatment showed poor results, and saw that the drug worked.

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    Bedaquiline and Delamanid, the only two most effective drugs against TB for more than 50 years are relatively much affordable and feasible as compared to the toxic drugs and excruciatingly painful injections.

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    To help doctors in these centres familiarise themselves with the new drug, doctors who found patients eligible for Bedaquiline filled in a form and sent it to the national clinical advisory committee.

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    Since 2016, when Bedaquiline was made available under the government's CAP, MSF is treating patients with complex drug resistance patterns, who need more new TB drugs--Bedaquiline, delamanid and add-on drug imipenem.

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    As Bedaquiline was the first new drug developed for TB--a life-threatening disease--in nearly 40 years and addressed an unmet need, it received accelerated approval before the third of three mandated clinical trial phases.

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    So when trials were finished, I approached the national department of health's head, Nobert Ndjeka, and I said it's(Bedaquiline) not a registered drug here, but I really think we need to start making a plan.

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