In many areas, Androstenedione is a controlled substance.
Androstenedione, in fact, increases production of testosterone, in women.
On the other path, Androstenedione is changed into estrone which will also
be converted into estradiol.
Androstenedione gained popularity as the supplement used by the baseball
homerun hitter Mark McGwire and other professional sports players.
Within 21days after the administration of the dose, the low levels of testosterone, Androstenedione, Dihydrotestosterone,
and Estradiol are able to get back to a normal range.
After cleavage of the side chain and using either the delta-5 or delta-4 pathway,
the key intermediary is Androstenedione, part of which is converted to the male hormone testosterone.
Investigators thinktowards theAnalysis shows that trilostane
is productive in suppressing the intracellular production of Androstenedione, testosterone,
and dihydrotestosterone in LNCaP-FGC prostate cancer cells and inhibiting cortisol biosynthesis within the human adrenal gland.
The adrenal glands are also known to produce Androstenedione in men,
but this contribution is nothing as compared to the overwhelming production of the other androgenic hormone, testosterone by the testes.
So we don't know if the supplement-popping guys who developed cancer were taking things like simple protein powders or
more serious products like Androstenedione- which the FDA has declared a“steroid
precursor” because it's converted to testosterone in the body.