acetanilide in A Sentence

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    Von Mering's claims remained essentially unchallenged for half a century, until two teams of researchers from the United States analyzed the metabolism of Acetanilide and paracetamol.

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    2

    It is the most commonly used non anti-inflammatory antipyretic analgesic, antipyretic effect similar to aspirin, the analgesic effect is weak, no anti rheumatic effects of anti inflammation, is the best varieties of Acetanilide drugs.

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    3

    It is the most commonly used non anti-inflammatory antipyretic analgesic, antipyretic effect similar to aspirin, the analgesic effect is weak, no anti rheumatic effects of anti inflammation, is the best varieties of Acetanilide drugs.

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    4

    Acetanilide was the first aniline derivative found to possess analgesic as well as antipyretic properties, and was quickly introduced into medical practice under the names of Antifebrin by A. Cahn and P. Hepp in 1886.

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    5

    In 1947 David Lester and Leon Greenberg found strong evidence that paracetamol was a major metabolite of Acetanilide in human blood, and in a subsequent study they reported that large doses of paracetamol given to albino rats did not cause methemoglobinemia.

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    6

    Paracetamol was synthesized for the first time in 1893, but it was not until 1948 that Brodie and Axelrod discovered that this white, odorless powder with a bitter taste is a breakdown product of the two aforementioned substances Acetanilide and phenacetin and responsible for their action.

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    7

    In three papers published in the September 1948 issue of the Journal of Pharmacology and Experimental Therapeutics, Bernard Brodie, Julius Axelrod and Frederick Flinn confirmed using more specific methods that paracetamol was the major metabolite of Acetanilide in human blood, and established that it was just as efficacious an analgesic as its precursor.

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